Biomarker analysis of rat livers exposed to different toxic pollutants (VOCs and PAHs) using an antibody array
- Title
- Biomarker analysis of rat livers exposed to different toxic pollutants (VOCs and PAHs) using an antibody array
- Author
- 황승용
- Keywords
- Antibody array; Biomarker assay; Environmental pollutants; PAHs; Protein chip; VOCs
- Issue Date
- 2010-09
- Publisher
- 한국바이오칩학회
- Citation
- BioChip Journal, v. 4, NO. 3, Page. 173-178
- Abstract
- We have developed an antibody microarray chip for biomarker analysis in rat livers exposed to five different toxic pollutants: volatile organic compounds (VOCs), dichloromethane, ethylbenzene, and trichloroethylene; and polycyclic aromatic hydrocarbons (PAHs), benzoanthracene and phenanthrene. The antibody chip consisted of antibodies against different biomarkers: alpha-2 μ globulin, glutathione S transferase (GST)-α, Hemoglobin β, and Phenylalanine hydroxylase. VOC- and PAH-treated rat livers showed differential expression patterns of the biomarker proteins. These results demonstrate that a protein chipbased antibody array is useful for the analysis of biomarkers induced by environmental toxic pollutants and can be a powerful tool to study the mechanisms of pollutants in biological samples. © The Korean BioChip Society and Springer 2010.
- URI
- https://link.springer.com/article/10.1007/s13206-010-4302-xhttps://repository.hanyang.ac.kr/handle/20.500.11754/181659
- ISSN
- 1976-0280;2092-7843
- DOI
- 10.1007/s13206-010-4302-x
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > ETC
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML