Enhanced Fluorescence by Controlled Surface Roughness of Plastic Biochip
- Title
- Enhanced Fluorescence by Controlled Surface Roughness of Plastic Biochip
- Author
- 박진구
- Issue Date
- 2011-06
- Publisher
- IOP Publishing Ltd
- Citation
- Japanese Journal of Applied Physics, v. 50, NO. 6, article no. 06GL14, Page. 1-4
- Abstract
- Fluoroimmunoassay is one of the protein detection methods in which the most critical parameter is fluorescence intensity as it determines the sensitivity of the analysis. In this study, cyclic olefin copolymer (COC) based plastic biochips of various thicknesses were fabricated from 304 SS (Stainless Steel) molds using imprinting technique. The effect of surface roughness of COC biochip on the enhancement of fluorescence intensity was investigated. The fluorescence intensity reached the maximum value at optimum value of surface roughness without significantly affecting the auto-fluorescence value. The process proposed in this technique is simple, low cost yet highly sensitive for protein detection. (c) 2011 The Japan Society of Applied Physics
- URI
- https://iopscience.iop.org/article/10.1143/JJAP.50.06GL14https://repository.hanyang.ac.kr/handle/20.500.11754/181228
- ISSN
- 0021-4922;1347-4065
- DOI
- 10.1143/JJAP.50.06GL14
- Appears in Collections:
- COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > MATERIALS SCIENCE AND CHEMICAL ENGINEERING(재료화학공학과) > Articles
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