Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이종민 | - |
dc.date.accessioned | 2022-12-06T05:52:54Z | - |
dc.date.available | 2022-12-06T05:52:54Z | - |
dc.date.issued | 2022-01 | - |
dc.identifier.citation | ALZHEIMERS RESEARCH & THERAPY, v. 14, NO. 1, article no. 6, Page. 1-12 | en_US |
dc.identifier.issn | 1758-9193 | en_US |
dc.identifier.uri | https://alzres.biomedcentral.com/articles/10.1186/s13195-021-00953-x | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/178034 | - |
dc.description.abstract | Background Neurofilament light chain (NFL) level has been suggested as a blood-based biomarker for neurodegeneration in dementia. However, the association between baseline NFL levels and cognitive stage transition or cortical thickness is unclear. This study aimed to investigate whether baseline NFL levels are associated with cognitive stage transition or cortical thickness in mild cognitive impairment (MCI) and cognitively unimpaired (CU) participants. Methods This study analyzed data on participants from the independent validation cohort of the Korea Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's disease (KBASE-V) study. Among the participants of KBASE-V study, 53 MCI and 146 CU participants who were followed up for >= 2 years and had data on the serum NFL levels were eligible for inclusion in this study. Participants were classified into three groups according to baseline serum NFL levels of low, middle, or high. Results The Kaplan-Meier analysis showed association between the serum NFL tertiles and risk of cognitive stage transition in MCI (P = 0.002) and CU (P = 0.028) participants, analyzed separately. The same is true upon analysis of MCI and CU participants together (P < 0.001). In MCI participants, the highest serum NFL tertile and amyloid-beta positivity were independent predictors for cognitive stage transition after adjusting for covariates. For CU participants, only amyloid-beta positivity was identified to be an independent predictor. Conclusion The study shows that higher serum NFL tertile levels correlate with increased risk of cognitive stage transition in both MCI and CU participants. Serum NFL levels were negatively correlated with the mean cortical thickness of the whole-brain and specific brain regions. | en_US |
dc.description.sponsorship | This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI20C0253, HU21C0007, HU21C0016, and HU21C0113), and a grant from the Brain Convergence Research Program of the National Research Foundation, funded by the Ministry of Science and ICT, Republic of Korea (NRF-2020M3E5D2A01084721 and NRF-2018M3A9F1023697). | en_US |
dc.language | en | en_US |
dc.publisher | BMC | en_US |
dc.source | 83732_이종민.pdf | - |
dc.subject | Neurofilament light chain | en_US |
dc.subject | Alzheimer's disease | en_US |
dc.subject | Cognitive stage | en_US |
dc.subject | Amyloid pathology | en_US |
dc.subject | Cortical thickness | en_US |
dc.title | Serum neurofilament light chain level as a predictor of cognitive stage transition | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 14 | - |
dc.identifier.doi | 10.1186/s13195-021-00953-x | en_US |
dc.relation.page | 1-12 | - |
dc.relation.journal | ALZHEIMERS RESEARCH & THERAPY | - |
dc.contributor.googleauthor | Lee, Eun-Hye | - |
dc.contributor.googleauthor | Kwon, Hyuk Sung | - |
dc.contributor.googleauthor | Koh, Seong-Ho | - |
dc.contributor.googleauthor | Choi, Seong Hye | - |
dc.contributor.googleauthor | Jin, Jeong-Hwa | - |
dc.contributor.googleauthor | Jeong, Jee Hyang | - |
dc.contributor.googleauthor | Jang, Jae-Won | - |
dc.contributor.googleauthor | Park, Kyung Won | - |
dc.contributor.googleauthor | Kim, Eun-Joo | - |
dc.contributor.googleauthor | Kim, Hee Jin | - |
dc.contributor.googleauthor | Hong, Jin Yong | - |
dc.contributor.googleauthor | Yoon, Soo Jin | - |
dc.contributor.googleauthor | Yoon, Bora | - |
dc.contributor.googleauthor | Kang, Ju-Hee | - |
dc.contributor.googleauthor | Lee, Jong-Min | - |
dc.contributor.googleauthor | Park, Hyun-Hee | - |
dc.contributor.googleauthor | Ha, Jungsoon | - |
dc.sector.campus | S | - |
dc.sector.daehak | 공과대학 | - |
dc.sector.department | 바이오메디컬공학전공 | - |
dc.identifier.pid | ljm | - |
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