Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이항락 | - |
dc.date.accessioned | 2022-11-02T06:54:20Z | - |
dc.date.available | 2022-11-02T06:54:20Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.citation | GASTRIC CANCER, v. 24, no. 1, page. 168-178 | en_US |
dc.identifier.issn | 1436-3291; 1436-3305 | en_US |
dc.identifier.uri | https://link.springer.com/article/10.1007/s10120-020-01103-2 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/176245 | - |
dc.description.abstract | Background: This study aimed to investigate risk factors for lymph node (LN) or distant metastasis after non-curative endoscopic resection (ER) of undifferentiated-type early gastric cancer (EGC). Methods: Of 1124 patients who underwent ER for undifferentiated-type gastric cancer at 18 tertiary hospitals across six geographic areas in Korea between 2005 and 2014, 634 with non-curative ER beyond the expanded criteria were retrospectively enrolled. According to the treatment after ER, patients were divided into additional surgery (n = 270) and follow-up (n = 364) groups. The median follow-up duration was 59 months for recurrence and 84 months for mortality. Results: LN metastasis was found in 6.7% (18/270) of patients at surgery. Ulcer [odds ratio (OR) 3.83; 95% confidence interval (CI) 1.21–12.13; p = 0.022] and submucosal invasion (OR 10.35; 95% CI 1.35–79.48; p = 0.025) were independent risk factors. In the follow-up group, seven patients (1.9%) developed LN or distant recurrence. Ulcer [hazard ratio (HR) 7.60; 95% CI 1.39–35.74; p = 0.018], LVI (HR 6.80; 95% CI 1.07–42.99; p = 0.042), and positive vertical margin (HR 6.71; 95% CI 1.28–35.19; p = 0.024) were independent risk factors. In the overall cohort, LN metastasis rates were 9.6% in patients with two or more risk factors and 1.2% in those with no or one risk factor. Conclusions: LVI, ulcer, submucosal invasion, and positive vertical margin are independently associated with LN or distant metastasis after non-curative ER of undifferentiated-type EGC. Surgical resection is strongly recommended for patients with two or more risk factors. | en_US |
dc.description.sponsorship | This work was supported by the Korean College of Helicobacter and Upper Gastrointestinal Research (Woon Geon Shin 2017 and Hyo-Joon Yang 2018) and by the National Research Foundation of Korea (Grant No. 2020R1G1A1010927). | en_US |
dc.language | en | en_US |
dc.publisher | SPRINGER | en_US |
dc.subject | Stomach neoplasms; Undiferentiated-type histology; Non-curative resection; Lymph node Metastasis; Risk factors | en_US |
dc.title | Risk factors of lymph node metastasis after non-curative endoscopic resection of undifferentiated-type early gastric cancer | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 24 | - |
dc.identifier.doi | 10.1007/s10120-020-01103-2 | en_US |
dc.relation.page | 168-178 | - |
dc.relation.journal | GASTRIC CANCER | - |
dc.contributor.googleauthor | Yang, Hyo-Joon | - |
dc.contributor.googleauthor | Jang, Jae-Young | - |
dc.contributor.googleauthor | Kim, Sang Gyun | - |
dc.contributor.googleauthor | Ahn, Ji Yong | - |
dc.contributor.googleauthor | Nam, Su Youn | - |
dc.contributor.googleauthor | Kim, Jie-Hyun | - |
dc.contributor.googleauthor | Min, Byung-Hoon | - |
dc.contributor.googleauthor | Lee, Wan-Sik | - |
dc.contributor.googleauthor | Lee, Bong Eun | - |
dc.contributor.googleauthor | Lee, Hang Lak | - |
dc.relation.code | 2021001335 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | alwayshang | - |
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