Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최보율 | - |
dc.date.accessioned | 2022-10-28T05:40:27Z | - |
dc.date.available | 2022-10-28T05:40:27Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v. 11, NO 1, article no. 4122, Page. 1-11 | en_US |
dc.identifier.issn | 2045-2322 | en_US |
dc.identifier.uri | https://www.nature.com/articles/s41598-021-82872-3 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/175975 | - |
dc.description.abstract | In Korea, subtype B is the predominant variant of HIV-1, but full genome sequencing and analysis of its viral variants are lacking. We performed near full-length genome (NFLG) sequencing and phylogenetic and recombination analyses of fifty plasma samples from HIV-positive men who have sex with men (MSM) from a Korea HIV/AIDS cohort study. Viral genomes were amplified and the near-full-length sequences were determined using next-generation sequencing (NGS) and Sanger sequencing. We focused on the HIV-1 subtype classification and identification of HIV recombinants. Twelve HIV-1 NFLGs were determined: ten were subtyped as pure HIV-1 subtype B and two recombinant strains as a common subtype CRF07_BC, and a novel subtype CRF43_02G recombined with CRF02_AG again, or a new CRF02_AG and subtype G recombinant. For the ten NFLGs determined by NGS, "the novel recombinant emerged at approximately 2003 and the other nine subtype B about 2004 or 2005". This is the first report analyzing HIV-1 NFLG, including recombinants and clinical characteristics, by subtype among MSM in Korea. Our results provide novel insights for understanding the recombinants in the HIV-1 epidemic in Korea. | en_US |
dc.description.sponsorship | This research was supported by an intramural grant of the Korea National Institute of Health (2017-NI51003-00), Korea HIV/AIDS cohort study (2016-ER5103-02), and National Biobank of Korea (KBN-2018-045) from the Korea Centers for Disease Control and Prevention, Korea. | en_US |
dc.language | en | en_US |
dc.publisher | NATURE RESEARCH | en_US |
dc.title | Characterization of HIV-1 recombinant and subtype B near full-length genome among men who have sex with men in South Korea | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 11 | - |
dc.identifier.doi | 10.1038/s41598-021-82872-3 | en_US |
dc.relation.page | 1-11 | - |
dc.relation.journal | SCIENTIFIC REPORTS | - |
dc.contributor.googleauthor | Ryou, Sangmi | - |
dc.contributor.googleauthor | Yoo, Myeongsu | - |
dc.contributor.googleauthor | Kim, Kisoon | - |
dc.contributor.googleauthor | Kim, Sangsoo | - |
dc.contributor.googleauthor | Kim, Sang Il | - |
dc.contributor.googleauthor | Kim, Youn Jeong | - |
dc.contributor.googleauthor | Park, Dae Won | - |
dc.contributor.googleauthor | Choi, Jun Yong | - |
dc.contributor.googleauthor | Kim, Hyo Youl | - |
dc.contributor.googleauthor | Choi, Bo Youl | - |
dc.relation.code | 2021002638 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | bychoi | - |
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