Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김종호 | - |
dc.date.accessioned | 2022-10-28T05:32:27Z | - |
dc.date.available | 2022-10-28T05:32:27Z | - |
dc.date.issued | 2014-08 | - |
dc.identifier.citation | Bulletin of the Korean Chemical Society, v. 35, NO. 8, Page. 2381-2384 | en_US |
dc.identifier.issn | 0253-2964;1229-5949 | en_US |
dc.identifier.uri | http://koreascience.or.kr/article/JAKO201423261321722.page | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/175967 | - |
dc.description.abstract | A solid-phase synthetic approach is reported for the synthesis of an ascorbic acid (ASA)-dipeptide conjugate that exhibited enhanced antioxidant activity. The N-terminal amino group of dipeptide (Ala-Ala) on a resin support was first activated by 1,1'-carbonyldiimidazole (CDI), and then reacted with an ASA derivative. The addition of a base, triethylamine (TEA), promoted nucleophilic acylation of ASA derivative and yielded a desired product (ASA-Ala-Ala) with enhanced purity, when cleaved from the resin. Compared to the approach where a C3 hydroxyl group of ASA was first activated with CDI and then reacted with the amino group of dipeptide on the resin, this new approach allowed a significant reduction of a total reaction time from 120 h to 8 h at 25 degrees C. As-prepared ASA-dipeptide conjugate (ASA-Ala-Ala) showed improved antioxidant activity compared to ASA. | en_US |
dc.description.sponsorship | This study was supported by the research fund of Hanyang University (HY-2013-P). | en_US |
dc.language | en | en_US |
dc.publisher | 대한화학회 | en_US |
dc.subject | Carbamate formation | en_US |
dc.subject | Ascorbic acid | en_US |
dc.subject | Peptide conjugate | en_US |
dc.subject | Antioxidant | en_US |
dc.subject | Solid-phase synthesis | en_US |
dc.title | Facile Synthetic Route to Ascorbic Acid-Dipeptide Conjugate via N-Terminal Activation of Peptide on Resin Support | en_US |
dc.type | Article | en_US |
dc.relation.no | 8 | - |
dc.relation.volume | 35 | - |
dc.identifier.doi | 10.5012/bkcs.2014.35.8.2381 | en_US |
dc.relation.page | 2381-2384 | - |
dc.relation.journal | Bulletin of the Korean Chemical Society | - |
dc.contributor.googleauthor | Yang, Jin-Kyoung | - |
dc.contributor.googleauthor | Kwak, Seon-Yeong | - |
dc.contributor.googleauthor | Jeon, Su-Ji | - |
dc.contributor.googleauthor | Kim, Hye-In | - |
dc.contributor.googleauthor | Kim, Jong-Ho | - |
dc.contributor.googleauthor | Lee, Yoon-Sik | - |
dc.sector.campus | E | - |
dc.sector.daehak | 공학대학 | - |
dc.sector.department | 재료화학공학과 | - |
dc.identifier.pid | kjh75 | - |
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