Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정미애 | - |
dc.date.accessioned | 2022-10-25T08:10:23Z | - |
dc.date.available | 2022-10-25T08:10:23Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.citation | TRANSPLANTATION PROCEEDINGS, v. 53, NO 1, Page. 427-435 | en_US |
dc.identifier.issn | 0041-1345 ; 1873-2623 | en_US |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0041134520328475?via%3Dihub | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/175820 | - |
dc.description.abstract | Background. Ischemia/reperfusion (IR) injury is 1 of the major problems in liver surgery. This study aims to evaluate the histologic and biochemical effects of dexmedetomidine on ischemia/reperfusion injury in the liver of rats. Methods. Twenty-two Sprague-Dawley male rats were separated into 3 groups: group sham, IR (IR injury), and IR-D (IR with dexmedetomidine). Ischemia was induced for 45 minutes with portal clampage and the reperfusion period was 120 minutes. Group IR-D received 3 mu g/kg of dexmedetomidine with loading for 10 minutes and then 3 mu g/ kg/h of dexmedetomidine was continuously injected intravenously 30 minutes before portal clampage. Biochemical factors (alanine aminotransferase and aspartate aminotransferase), variable cytokines (B cell lymphoma-2 (Bcl-2), Bax, caspase 3, caspase 8, nuclear factor-kappa B, interleukin (IL)-1 beta, IL-6, IL-10, mixed lineage kinase domain-like protein, and receptor-interacting protein kinase-3), and histologic findings were investigated. Results. Dexmedetomidine preconditioning significantly suppressed the histologic damage. In the IR-D group, the expression of IL-6 was decreased and the Bcl-2 was increased when compared with the IR group. Conclusion. Dexmedetomidine suppresses hepatic IR injury and the protective mechanism appears to involve the decrease of IL-6 and upregulation of Bcl-2 expression, which result in the attenuation of inflammatory response and the inhibition of apoptosis. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCIENCE INC | en_US |
dc.title | The Protective Effects of Dexmedetomidine Preconditioning on Hepatic Ischemia/Reperfusion Injury in Rats | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 53 | - |
dc.identifier.doi | 10.1016/j.transproceed.2020.10.014 | en_US |
dc.relation.page | 427-435 | - |
dc.relation.journal | TRANSPLANTATION PROCEEDINGS | - |
dc.contributor.googleauthor | Lim, Hyunyoung | - |
dc.contributor.googleauthor | Kim, Tae Yeon | - |
dc.contributor.googleauthor | Kim, Soo Yeon | - |
dc.contributor.googleauthor | Ro, Soo Jin | - |
dc.contributor.googleauthor | Koh, Su Rim | - |
dc.contributor.googleauthor | Ryu, Sun | - |
dc.contributor.googleauthor | Ko, Justin Sangwook | - |
dc.contributor.googleauthor | Jeong, Mi Ae | - |
dc.relation.code | 2021007364 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | macheong | - |
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