Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김미경 | - |
dc.date.accessioned | 2022-10-24T05:13:12Z | - |
dc.date.available | 2022-10-24T05:13:12Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.citation | ENDOCRINE JOURNAL, v. 68, NO 6, Page. 701-711 | en_US |
dc.identifier.issn | 1348-4540; 0918-8959 | en_US |
dc.identifier.uri | https://www.jstage.jst.go.jp/article/endocrj/68/6/68_EJ20-0519/_article | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/175721 | - |
dc.description.abstract | Only limited information is available on the inter-relationships between genetic and non-genetic factors such as diet and sunlight exposure with serum 25-hydroxyvitamin D [25(OH)D] concentration. This cross-sectional study aimed to examine the independent and interactive associations of season, dietary vitamin D intake, and SNPs of 11 vitamin D-related candidate genes with serum 25(OH)D concentration among 2,721 adults aged ˃= 40 years at baseline from the Yangpyeong cohort, a part of the Korean Genome Epidemiology Study (KoGES). The interactions between season or dietary vitamin D and 556 SNPs were evaluated using 2-degree of freedom joint tests. Season was strongly (p(difference) = 1.00 x 10(-12)) and dietary vitamin D intake was slightly but significantly associated with serum 25(OH)D concentration (p(difference) = 0.0119). Among five SNPs (rs11723621-GC, rs7041-GC, rs10500804-CYP2R/, rs7129781-C YP2R1, and rs2852853-DIXR7) identified in the screening steps, only one, rs10500804-CYP2R1, significantly interacted with season (p(interaction) = 8.01 x 10(-5)). The inverse association between number of minor alleles of rs10500804-CYP2R/and concentration of 25(OH)D was significant only in summer/fall. Conversely, dietary vitamin D intake was positively associated only in winter/spring. in conclusion, season, dietary vitamin D intake, and four SNPs in GC, CYP2R1, and DHCR7 are independently and rs10500804-CYP2R/ is interactively associated with serum 25(OH)D concentration. Serum 25(OH)D is influenced by genotype of rs10500804-CIP2R1 in summerlfall when sunlight exposure is high, while dietary vitamin D intake is an important determinant of serum 25(OH)D during the seasons with low cutaneous vitamin D synthesis. | en_US |
dc.description.sponsorship | This work was supported by the Research Program funded by the Korea Centers for Disease Control and National Research Foundation of Korea grant funded by the Korean government (Ministry of Science, ICT, & Future Planning) (No.2016R1A2B2011352) ; and the Collaborative Genome Program for Fostering New PostGenome Industry of the National Research Foundation (NRF) funded by the Ministry of Science and ICT (MSIT) (NRF2017M3C9A6047623) . | en_US |
dc.language.iso | en | en_US |
dc.publisher | JAPAN ENDOCRINE SOC | en_US |
dc.subject | Vitamin D; 25-Hydrox-yvitamin D; Season; Dietary vitamin D intake | en_US |
dc.title | Independent and interactive associations of season, dietary vitamin D, and vitamin D-related genetic variants with serum 25(OH)D in Korean adults aged 40 years or older | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 68 | - |
dc.relation.page | 701-711 | - |
dc.relation.journal | ENDOCRINE JOURNAL | - |
dc.contributor.googleauthor | Lee, Jiseon | - |
dc.contributor.googleauthor | Woo, Hye Won | - |
dc.contributor.googleauthor | Kim, Jihye | - |
dc.contributor.googleauthor | Shin, Min-Ho | - |
dc.contributor.googleauthor | Koh, InSong | - |
dc.contributor.googleauthor | Choi, Bo Youl | - |
dc.contributor.googleauthor | Kim, Mi Kyung | - |
dc.relation.code | 2021008245 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kmkkim | - |
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