Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김현성 | - |
dc.date.accessioned | 2022-10-17T00:36:37Z | - |
dc.date.available | 2022-10-17T00:36:37Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.citation | IN VIVO, v. 35, no. 1, page. 131-140 | en_US |
dc.identifier.issn | 0258-851X ; 1791-7549 | en_US |
dc.identifier.uri | https://iv.iiarjournals.org/content/35/1/131 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/175429 | - |
dc.description.abstract | Background/Aim: Dual-specificity protein phosphatase 4 (DUSP4) negatively regulates MAPK signaling and is involved in various cellular processes. We herein evaluated the relationship between DUSP4 expression and clinicopathological characteristics in a large series of gastric cancer samples. Materials and Methods: DUSP4 expression was examined by brununohistochemistry in 508 gastric cancer samples. Cases were classified according to the TCGA molecular classification and HER2 amplification. Kaplan-Meier plots were used to predict the relationship between mRNA expression of DUSP4 and survival. Results: Low expression of DUSP4 was significantly correlated with larger tumor size, higher pT category, positive nodal status, higher stage, lymphovascular invasion, perineural invasion, worse overall survival, and worse recurrence-free survival. No correlation was observed between DUSP4 expression and molecular characteristics. Bioinformatics analysis showed that low mRNA expression was associated with a poor prognosis. Conclusion: Low expression of DUSP4 is associated with aggressive phenotypes of gastric cancer and a poor prognosis. | en_US |
dc.description.sponsorship | This research was supported by Grants from the Medical Research Center (2017R1A5A2015395) and funded by the National Research Foundation (NRF) of the Ministry of Education, Science and Technology (MEST). | en_US |
dc.language.iso | en | en_US |
dc.publisher | INT INST ANTICANCER RESEARCH | en_US |
dc.subject | Gastric cancer; DUSP4; dual-specificity protein phosphatase 4; prognosis | en_US |
dc.title | Low DUSP4 Expression Is Associated With Aggressive Phenotypes and Poor Prognosis in Gastric Cancer | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.21873/invivo.12240 | en_US |
dc.relation.journal | IN VIVO | - |
dc.contributor.googleauthor | Bang, Seongsik | - |
dc.contributor.googleauthor | Jee, Seungyun | - |
dc.contributor.googleauthor | Kim, Hyunsung | - |
dc.contributor.googleauthor | Jang, Kiseok | - |
dc.contributor.googleauthor | Park, Hosub | - |
dc.contributor.googleauthor | Myung, Jae Kyung | - |
dc.contributor.googleauthor | Choi, Dongho | - |
dc.contributor.googleauthor | Shin, Su-Jin | - |
dc.contributor.googleauthor | Paik, Seung Sam | - |
dc.relation.code | 2021001316 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hhnt5841 | - |
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