Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김태환 | - |
dc.date.accessioned | 2022-09-19T02:38:53Z | - |
dc.date.available | 2022-09-19T02:38:53Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.citation | JOURNAL OF CLINICAL MEDICINE, v. 9, no. 12, article no. 3968, page. 1-12 | en_US |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://www.mdpi.com/2077-0383/9/12/3968 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/172941 | - |
dc.description.abstract | Background: Patients with ankylosing spondylitis (AS) have increased levels of protein phosphatase magnesium-dependent 1A (PPM1A) and autoantibodies. We evaluated the usefulness of serum anti-PPM1A antibodies as a biomarker for AS. Methods: Serum samples from 58 AS patients were obtained from a multicenter registry prior to the initiation of anti-TNF agents. The serum levels of anti-PPM1A antibodies were measured using ELISA. Spinal radiographic progression was defined as an increase in the modified stoke ankylosing spondylitis spinal score (mSASSS) by ≥2 units or a newly developed syndesmophyte. The role of exogenous PPM1A on bone mineralization was evaluated using primary osteoprogenitors acquired from patients with AS and non-inflammatory controls. Results: The baseline levels of anti-PPM1A antibodies and mSASSS were higher in the radiographic progression group than in the non-progression group. In logistic regression analysis, baseline mSASSS and serum anti-PPM1A antibodies were associated with a higher risk of progression. The level of anti-PPM1A antibodies for predicting progression had an AUC of 0.716 (cut-off value: 43.77 ng/mL). PPM1A stimulation increased matrix mineralization in AS-osteoprogenitors but not in controls. Conclusion: Along with mSASSS, the serum levels of anti-PPM1A antibodies might be useful as a predictor of radiographic progression after treatment with anti-TNF agents. | en_US |
dc.description.sponsorship | This research was funded by the National Research Foundation of Korea, grant number NRF-2019-R1F1A1059736. | en_US |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.subject | ankylosing spondylitis | en_US |
dc.subject | autoantibody | en_US |
dc.subject | biomarkers | en_US |
dc.subject | protein phosphatase magnesium-dependent 1 A | en_US |
dc.subject | radiographic progression | en_US |
dc.title | Autoantibodies against Protein Phosphatase Magnesium‐Dependent 1A as a Biomarker for Predicting Radiographic Progression in Ankylosing Spondylitis Treated with Anti‐Tumor Necrosis Factor Agents | en_US |
dc.type | Article | en_US |
dc.relation.no | 12 | - |
dc.relation.volume | 9 | - |
dc.identifier.doi | 10.3390/jcm9123968 | - |
dc.relation.page | 1-12 | - |
dc.relation.journal | JOURNAL OF CLINICAL MEDICINE | - |
dc.contributor.googleauthor | Lee, Jung-Sun | - |
dc.contributor.googleauthor | Lee, Eun-Ju | - |
dc.contributor.googleauthor | Lee, Jae-Hyun | - |
dc.contributor.googleauthor | Hong, Seok-Chan | - |
dc.contributor.googleauthor | Lee, Chang-Keun | - |
dc.contributor.googleauthor | Yoo, Bin | - |
dc.contributor.googleauthor | Oh, Ji-Seon | - |
dc.contributor.googleauthor | Lee, Sang-Hoon | - |
dc.contributor.googleauthor | Kim, Tae-Jong | - |
dc.contributor.googleauthor | Kim, Tae-Hwan | - |
dc.relation.code | 2020047025 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | thkim | - |
dc.identifier.researcherID | M-3962-2017 | - |
dc.identifier.orcid | https://orcid.org/0000-0002-3542-2276 | - |
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