Immunosuppressive Activity of Cepacidine A, a Novel Antifungal Antibiotic Produced by Pseudomonas cepacia
- Title
- Immunosuppressive Activity of Cepacidine A, a Novel Antifungal Antibiotic Produced by Pseudomonas cepacia
- Author
- 이철훈
- Keywords
- Antifungal antibiotic; cepacidine A; immunosuppressive activity
- Issue Date
- 1999-10
- Publisher
- KSAM, Springer Verlag
- Citation
- In: Journal of Microbiology and Biotechnology. (Journal of Microbiology and Biotechnology, October 1999, 9(5):672-674)
- Abstract
- Cepacidine A was first identified as a novel antifungal antibiotic which was isolated from the culture broth of Pseudomonas cepacia AF2001. It showed a potent in vitro antifungal activity against various pathogenic fungi, but did not show any activity against bacteria. Recently, the immunosuppressive action of cepacidine A was discovered using an in vitro screening system involving inhibition of the proliferation of murine lymphocytes stimulated by 2 mitogens, and also by in. vivo mouse models involving inhibition of delayed type hypersensitivity and SRBC hemagglutination. Cepacidine A showed a significant activity of cellular immunosuppression (ED50) at concentration levels of 1-3 mg/kg, i.p.. Unfortunately, the delayed toxicity at a dose of above 3 mg/kg i.p. was apparent.
- URI
- https://www.koreascience.or.kr/article/JAKO199911922245309.pagehttps://repository.hanyang.ac.kr/handle/20.500.11754/171476
- ISSN
- 10177825
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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