The Therapeutic Role of Nanoparticle Shape in Traumatic Brain Injury : An in vitro Comparative Study
- Title
- The Therapeutic Role of Nanoparticle Shape in Traumatic Brain Injury : An in vitro Comparative Study
- Author
- 유효종
- Keywords
- Traumatic brain injury; Cerium oxide; Nanoparticles
- Issue Date
- 2022-02
- Publisher
- KOREAN NEUROSURGICAL SOC
- Citation
- JOURNAL OF KOREAN NEUROSURGICAL SOCIETY, v. 65, NO 2, Page. 196-203
- Abstract
- Objective : To perform a comparative analysis of therapeutic effects associated with two different shapes of ceria nanoparticles, ceria nanorods (Ceria NRs) and ceria nanospheres (Ceria NSs), in an in vitro model of traumatic brain injury (TBI). Methods : In vitro TBI was induced using six-well confluent plates by manually scratching with a sterile pipette tip in a 6x6-square grid. The cells were then incubated and classified into cells with scratch injury without nanoparticles and cells with scratch injury, which were treated separately with 1.16 mM of Ceria NSs and Ceria NRs. Antioxidant activities and anti-inflammatory effects were analyzed. Results : Ceria NRs and Ceria NSs significantly reduced the level of reactive oxygen species compared with the control group of SH-SY5Y cells treated with Dulbecco's phosphate-buffered saline. The mRNA expression of superoxide dismutases was also reduced in nanoparticle-treated SH-SY5Y cells, but apparently the degree of mRNA expression decrease was not dependent on the nanoparticle shape. Exposure to ceria nanoparticles also decreased the cyclooxygenase-2 expression, especially prominent in Ceria NR-treated group than that in Ceria NS-treated group. Conclusion : Ceria nanoparticles exhibit antioxidant and anti-inflammatory effects in TBI models in vitro. Ceria NRs had better antiinflammatory effect than Ceria NSs, but showed similar antioxidant activity.
- URI
- https://www.jkns.or.kr/journal/view.php?doi=10.3340/jkns.2021.0185https://repository.hanyang.ac.kr/handle/20.500.11754/171060
- ISSN
- 20053711; 15987876
- DOI
- 10.3340/jkns.2021.0185
- Appears in Collections:
- COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > MATERIALS SCIENCE AND CHEMICAL ENGINEERING(재료화학공학과) > Articles
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