Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김웅 | - |
dc.date.accessioned | 2022-03-16T01:45:02Z | - |
dc.date.available | 2022-03-16T01:45:02Z | - |
dc.date.issued | 2020-02 | - |
dc.identifier.citation | SENSORS AND ACTUATORS B-CHEMICAL, v. 304, article no. 127424 | en_US |
dc.identifier.issn | 0925-4005 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0925400519316235?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/169105 | - |
dc.description.abstract | Cortisol, which is a stress biomarker that causes various mental disorders, is found in sweat, saliva, blood, and urine. Because mental disorders resulting from stress are a silent contributor to various diseases, the detection of cortisol level is an important step in their prevention. Here, we developed a highly sensitive, localized surface plasmon resonance (LSPR) aptasensor for the direct detection of cortisol in saliva. The LSPR aptasensor was constructed using gold nanoparticles of different sizes. Subsequently, the surface of the LSPR substrate was immobilized using an aptamer for capturing cortisol. The detection capability of the LSPR aptasensor was compared with that of the antibody- immobilized sensor. The LSPR aptasensor displayed excellent detection capability for a wide range of cortisol concentrations extending from 0.1–1000 nM with a detection limit of 0.1 nM. In addition, the LSPR aptasensor was able to selectively detect cortisol among other substances with similar chemical structures (e.g., cortisone, corticosterone, progesterone, and triamcinolone). These results indicate that the LSPR aptasensor may be used for the highly sensitive and selective detection of cortisol in salivary samples. | en_US |
dc.description.sponsorship | This work was supported by a National Research Foundation of Korea (NRF) grant, funded by the Korean government (NRF-2017M3A9F1031229, NRF-2017R1E1A1A01075439 and NRF-2019R1A2C3009595) and was conducted with the support of the Korea Environment Industry & Technology Institute (KEITI) through its Ecological Imitation-based Environmental Pollution Management Technology Development Project, and funded by the Korea Ministry of Environment (MOE) (2019002800009) | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCIENCE SA | en_US |
dc.subject | Cortisol | en_US |
dc.subject | Aptasensor | en_US |
dc.subject | Localized surface plasmon resonance | en_US |
dc.subject | Gold nanoparticles | en_US |
dc.subject | Human saliva | en_US |
dc.title | Localized surface plasmon resonance aptasensor for the highly sensitive direct detection of cortisol in human saliva | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.snb.2019.127424 | - |
dc.relation.journal | SENSORS AND ACTUATORS B-CHEMICAL | - |
dc.contributor.googleauthor | Jo, Seongjae | - |
dc.contributor.googleauthor | Lee, Wonseok | - |
dc.contributor.googleauthor | Park, Joohyung | - |
dc.contributor.googleauthor | Kim, Woong | - |
dc.contributor.googleauthor | Kim, Woochang | - |
dc.contributor.googleauthor | Lee, Gyudo | - |
dc.contributor.googleauthor | Lee, Heon-Jeong | - |
dc.contributor.googleauthor | Hong, unghwa | - |
dc.contributor.googleauthor | Park, Jinsung | - |
dc.relation.code | 2020046536 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | SCHOOL OF MECHANICAL ENGINEERING | - |
dc.identifier.pid | oong0331 | - |
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