Metabolically engineered stem cell-derived exosomes to regulate macrophage heterogeneity in rheumatoid arthritis
- Title
- Metabolically engineered stem cell-derived exosomes to regulate macrophage heterogeneity in rheumatoid arthritis
- Author
- 조용우
- Issue Date
- 2021-06
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Citation
- SCIENCE ADVANCES, v. 7, No. 23, Article no. eabe0083, 13pp
- Abstract
- Despite the remarkable advances in therapeutics for rheumatoid arthritis (RA), a large number of patients still lack effective countermeasures. Recently, the reprogramming of macrophages to an immunoregulatory phenotype has emerged as a promising therapeutic strategy for RA. Here, we report metabolically engineered exosomes that have been surface-modified for the targeted reprogramming of macrophages. Qualified exosomes were readily harvested from metabolically engineered stem cells by tangential flow filtration at a high yield while maintaining their innate immunomodulatory components. When systemically administered into mice with collagen-induced arthritis, these exosomes effectively accumulated in the inflamed joints, inducing a cascade of anti-inflammatory events via macrophage phenotype regulation. The level of therapeutic efficacy obtained with bare exosomes was achievable with the engineered exosomes of 10 times less dose. On the basis of the boosted nature to reprogram the synovial microenvironment, the engineered exosomes display considerable potential to be developed as a next-generation drug for RA.
- URI
- https://advances.sciencemag.org/content/7/23/eabe0083https://repository.hanyang.ac.kr/handle/20.500.11754/166606
- ISSN
- 2375-2548
- DOI
- 10.1126/sciadv.abe0083
- Appears in Collections:
- COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > MATERIALS SCIENCE AND CHEMICAL ENGINEERING(재료화학공학과) > Articles
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