Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박보영 | - |
dc.date.accessioned | 2021-10-26T01:08:38Z | - |
dc.date.available | 2021-10-26T01:08:38Z | - |
dc.date.issued | 2020-04 | - |
dc.identifier.citation | CLINICAL ENDOCRINOLOGY, v. 93, no. 3, page. 238-247 | en_US |
dc.identifier.issn | 0300-0664 | - |
dc.identifier.issn | 1365-2265 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/10.1111/cen.14206 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/165731 | - |
dc.description.abstract | Objective: Type 2 deiodinase (DIO2)-mediated thyroid hormone synthesis stimulates osteoblast activity and increases the expression of osteoblast differentiation markers, but there are no large cohort studies to identify the role of the DIO2 polymorphism in bone mineral density in humans. Methods: To investigate the hypothesis that individuals with the DIO2 gene polymorphism are susceptible to osteoporosis, we assessed the polymorphism of the DIO2 gene in 7,524 Koreans drawn from the large-scale Ansan-Anseong cohort of the Korean Genome and Epidemiology Study. All of the participants underwent genotyping of the DIO2 Thr92Ala polymorphism (rs225014). Results: A total of 6,022 participants were recruited; 1991 (33.0%) were homozygous for the Thr allele, 2,967 (49.3%) were heterozygous (Thr/Ala), and 1064 (17.7%) were homozygous for the Ala allele. The effects of the DIO2 Thr92Ala polymorphism on axial speed of sound (SOS) and the T-score in the tibia and radius were assessed, with age, gender, oestrogen status, body mass index (BMI), serum calcium, 25-hydroxyvitamin D, and parathyroid hormone (PTH) included as covariables. Female subjects carrying the DIO2 Thr92Ala polymorphism had significantly lower SOS and T-scores than control participants. Cox regression analysis revealed a significant relationship between the DIO2 polymorphism and diagnosis of osteoporosis in female participants. Conclusion: DIO2 Thr92Ala polymorphism is associated with decreased SOS and T-scores in the tibia of female subjects independent of other clinical parameters, where this indicates a potential functional role of DIO2 in the maintenance of bone mineral density. | en_US |
dc.description.sponsorship | This work was supported by the Korean Endocrine Society of New Faculty Research Award, 2018. Hyon-Seung Yi was also supported by the Basic Science Research Program, National Research Foundation, Ministry of Science and ICT, Future Planning, Korea (NRF-2018R1C1B6004439). Young Mi Kang and Yea Eun Kang were supported by the Basic Science Research Program, National Research Foundation, Ministry of Science and ICT, Future Planning, Korea (NRF-2017R1D1A1B03027820). | en_US |
dc.language.iso | en | en_US |
dc.publisher | WILEY | en_US |
dc.subject | bone mineral density | en_US |
dc.subject | osteoporosis | en_US |
dc.subject | polymorphism | en_US |
dc.subject | Type 2 deiodinase | en_US |
dc.title | Type 2 deiodinase Thr92Ala polymorphism is associated with a reduction in bone mineral density: A community-based korean genome and epidemiology study | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 93 | - |
dc.identifier.doi | 10.1111/cen.14206 | - |
dc.relation.page | 238-247 | - |
dc.relation.journal | CLINICAL ENDOCRINOLOGY | - |
dc.contributor.googleauthor | Kang, Yea Eun | - |
dc.contributor.googleauthor | Kang, Young Mi | - |
dc.contributor.googleauthor | Park, Boyoung | - |
dc.contributor.googleauthor | Shong, Minho | - |
dc.contributor.googleauthor | Yi, Hyon-Seung | - |
dc.relation.code | 2020053068 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hayejine | - |
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