Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 문지용 | - |
dc.date.accessioned | 2021-09-27T01:46:09Z | - |
dc.date.available | 2021-09-27T01:46:09Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.citation | RESPIRATORY MEDICINE, v. 163, article no. 105890 | en_US |
dc.identifier.issn | 0954-6111 | - |
dc.identifier.issn | 1532-3064 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0954611120300305?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/165137 | - |
dc.description.abstract | Background: Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of vitamin D deficiency. Vitamin D levels also correlate with lung function in patients with COPD. However, there are few reports on vitamin D deficiency and emphysema severity in COPD. This study aimed to investigate the effects of plasma 25-hydroxyvitamin D (25-OHD) level on emphysema severity in male COPD patients. Methods: A total of 151 male subjects were selected from the Korean Obstructive Lung Disease (KOLD) cohort. Subjects were subdivided into four subgroups according to their baseline plasma 25-OHD level: sufficiency (˃= 20 ng/ml), mild deficiency (15-20 ng/ml), moderate deficiency (10-15 ng/ml), and severe deficiency (˂10 ng/ml). Results: Baseline computed tomography (CT) emphysema indices revealed significant differences among the subgroups (p = 0.034). A statistically significant difference was also observed among the subgroups regarding change in the CT emphysema index over 3 years (p = 0.047). The annual increase in emphysema index was more prominent in the severe deficiency group (1.34% per year) than in the other groups (0.41% per year) (p = 0.003). Conclusions: This study demonstrates that CT emphysema indices were different among the four subgroups and supports that severe vitamin D deficiency is associated with rapid progression of emphysema in male patients with COPD. | en_US |
dc.description.sponsorship | This work was supported by a research grant from Jeju National University Hospital in 2018. | en_US |
dc.language.iso | en | en_US |
dc.publisher | W B SAUNDERS CO LTD | en_US |
dc.subject | Chronic obstructive pulmonary disease | en_US |
dc.subject | Emphysema | en_US |
dc.subject | Vitamin D | en_US |
dc.title | Severe vitamin D deficiency is associated with emphysema progression in male patients with COPD | en_US |
dc.type | Article | en_US |
dc.relation.volume | 163 | - |
dc.identifier.doi | 10.1016/j.rmed.2020.105890 | - |
dc.relation.page | 1-6 | - |
dc.relation.journal | RESPIRATORY MEDICINE | - |
dc.contributor.googleauthor | Kim, Changhwan | - |
dc.contributor.googleauthor | Ko, Yousang | - |
dc.contributor.googleauthor | Jung, Ji Ye | - |
dc.contributor.googleauthor | Lee, Jae Seung | - |
dc.contributor.googleauthor | Rhee, Chin Kook | - |
dc.contributor.googleauthor | Lee, Jin Hwa | - |
dc.contributor.googleauthor | Lee, Ji-Hyun | - |
dc.contributor.googleauthor | Moon, Ji-Yong | - |
dc.contributor.googleauthor | Lim, Seong Yong | - |
dc.contributor.googleauthor | Yoo, Kwang Ha | - |
dc.relation.code | 2020054609 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | moonji | - |
dc.identifier.researcherID | U-1476-2018 | - |
dc.identifier.orcid | http://orcid.org/0000-0003-2459-3448 | - |
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