Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신정훈 | - |
dc.date.accessioned | 2021-07-07T01:52:58Z | - |
dc.date.available | 2021-07-07T01:52:58Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.citation | AMERICAN JOURNAL OF CARDIOLOGY, v. 125, no. 6, page. 866-873 | en_US |
dc.identifier.issn | 0002-9149 | - |
dc.identifier.issn | 1879-1913 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S000291491931505X?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/162693 | - |
dc.description.abstract | The purpose of this study was to compare Friedewald-calculated and directly measured low-density lipoprotein cholesterol (LDL-C) levels. LDL-C is routinely estimated by the Friedewald formula in clinical practice. However, unreliability of the Friedewald-calculated LDL-C appears at lower LDL-C level or high triglyceride levels. We examined 147,143 Korean adults who underwent a comprehensive health examination in 2017. After excluding subjects with calculated Friedewald LDL-C <0 and triglyceride levels >= 400 mg/dL, 145,043 subjects (female; 43%, mean age; 42 +/- 8) were analyzed. Friedewald-calculated LDL-C levels were approximately 15 mg/dL lower to directly measured LDL-C. Friedewald measurement had high sensitivity (79.2%, 82.2% of sensitivity in males and 74.5% of sensitivity in females) and specificity (100%) for directly measured LDL-C cut-off value of >= 100 mg/dL in all levels of triglyceride. In 82% of total subjects, LCL-C measured by both methods differed by more than 10 mg/dL. The proportion of reclassification between both methods for National Cholesterol Education Program categories of risk was 50.3% of patients with Friedewald measurement of LDL-C <70 mg/dL, 68% had directly measured LDL-C >= 70 mg/dL. Direct and Freidewald measurements of LDL-C levels are well correlated. However, concordance of both methods is low and reclassification between both is substantial for NECP categories of risk. Thus, it is desirable to make a global consensus on the LDL-C measurement. | en_US |
dc.language.iso | en | en_US |
dc.publisher | EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC | en_US |
dc.subject | LDL-CHOLESTEROL | en_US |
dc.subject | FORMULA | en_US |
dc.subject | PLASMA | en_US |
dc.subject | HDL | en_US |
dc.title | Comparison of Low-Density Lipoprotein Cholesterol Concentrations by Direct Measurement and by Friedewald Calculation | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.amjcard.2019.12.036 | - |
dc.relation.page | 866-873 | - |
dc.relation.journal | AMERICAN JOURNAL OF CARDIOLOGY | - |
dc.contributor.googleauthor | Sung, Ki-Chul | - |
dc.contributor.googleauthor | Kwon, Chang Hee | - |
dc.contributor.googleauthor | Lee, Mi Yeon | - |
dc.contributor.googleauthor | Kwon, Min-Jung | - |
dc.contributor.googleauthor | Lee, Ju Hee | - |
dc.contributor.googleauthor | Jung, Mi-Hyang | - |
dc.contributor.googleauthor | Shin, Jeong-Hun | - |
dc.relation.code | 2020045704 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hyapex | - |
dc.identifier.researcherID | O-1273-2019 | - |
dc.identifier.orcid | http://orcid.org/0000-0002-6718-9763 | - |
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