Dopa Responsive Parkinsonism in an Early Onset Alzheimer's Disease Patient with a Presenilin 1 Mutation (A434T)
- Title
- Dopa Responsive Parkinsonism in an Early Onset Alzheimer's Disease Patient with a Presenilin 1 Mutation (A434T)
- Author
- 박종은
- Keywords
- Alzheimer's disease; FP-CIT PET; L-dopa; parkinsonism; presenilin 1
- Issue Date
- 2019-09
- Publisher
- IOS Press
- Citation
- Journal of Alzheimer's Disease, v. 71, no. 1, page. 7-13
- Abstract
- Alzheimer's disease patients with presenilin 1 (PSEN1) mutations commonly show parkinsonism in addition to dementia. Yet, whether these patients show dopaminergic deficit and response to L-dopa is largely unknown. We report a 43-year-old woman with a PSEN1 mutation (A434T) who showed right side dominant parkinsonism. As disease progressed, she developed bilateral parkinsonism which was markedly relieved by L-dopa. Amyloid (Florbetaben) positron-emission tomography (PET) showed cortical florbetaben uptake, relatively sparing the striatum. Initial dopamine transporter (FP-CIT) PET showed asymmetrically decreased FP-CIT uptake in the left striatum. We suggest that in Alzheimer's disease patients with PSEN1 mutation, parkinsonism may be relieved by L-dopa when it is associated with presynaptic dopaminergic deficit.
- URI
- https://content.iospress.com/articles/journal-of-alzheimers-disease/jad190469https://repository.hanyang.ac.kr/handle/20.500.11754/161904
- ISSN
- 1387-2877; 1875-8908
- DOI
- 10.3233/JAD-190469
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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