Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이영한 | - |
dc.date.accessioned | 2021-02-25T01:39:42Z | - |
dc.date.available | 2021-02-25T01:39:42Z | - |
dc.date.issued | 2001-10 | - |
dc.identifier.citation | Carcinogenesis, v. 22, issue. 10, page. 1633-1639 | en_US |
dc.identifier.issn | 0143-3334 | - |
dc.identifier.issn | 1460-2180 | - |
dc.identifier.uri | https://academic.oup.com/carcin/article/22/10/1633/2733697 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/160025 | - |
dc.description.abstract | Resveratrol has been shown to induce anti-proliferation and apoptosis of human cancer cell lines. In the present study, we determined the effect of high intracellular levels of the anti-apoptosis protein Bcl-2 on caspase-3 activation, PLC-γ1 degradation and cytochrome c release during resveratrol-induced apoptosis. For this, we used U937/vector and U937/Bcl-2 cells, which were generated by transfection of the cDNA of the Bcl-2 gene. As compared with U937/vector, U937/Bcl-2 cells exhibited a 4-fold greater expression of Bcl-2. Treatment with 60 or 100 μM resveratrol for 24 h produced morphological features of apoptosis and DNA fragmentation in U937/vector cells, respectively. This was associated with caspase-3 activation and PLC-γ1 degradation. In contrast, resveratrol-induced caspase-3 activation and PLC-γ1 degradation and apoptosis were significantly inhibited in U937/Bcl-2 cells. Bcl-2 overexpressing cells exhibited less cytochrome c release and sustained expression levels of the IAP proteins during resveratrol-induced apoptosis. In addition, these findings indicate that Bcl-2 inhibits resveratrol-induced apoptosis by a mechanism that interferes with cytochrome c release and activity of caspase-3 that is involved in the execution of apoptosis. | en_US |
dc.description.sponsorship | This study was supported by a grant (01-PJ1-PG3-20800-0026) of the Korea Health 21 R&D Project, Ministry of Health & Welfare, South Korea. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | OXFORD UNIV PRESS | en_US |
dc.title | Bcl-2 overexpression attenuates resveratrol-induced apoptosis in U937 cells by inhibition of caspase-3 activity | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1093/carcin/22.10.1633 | - |
dc.relation.journal | CARCINOGENESIS | - |
dc.contributor.googleauthor | Park, Jong-Wook | - |
dc.contributor.googleauthor | Choi, Yun-Jung | - |
dc.contributor.googleauthor | Suh, Seong-Il | - |
dc.contributor.googleauthor | Baek, Won-Ki | - |
dc.contributor.googleauthor | Suh, Min-Ho | - |
dc.contributor.googleauthor | Jin, Ing-Nyol | - |
dc.contributor.googleauthor | Min, Do Sik | - |
dc.contributor.googleauthor | Woo, Ju-Hyung | - |
dc.contributor.googleauthor | Chang, Jong-Soo | - |
dc.contributor.googleauthor | Passaniti, Antonino | - |
dc.contributor.googleauthor | Lee, Young Han | - |
dc.contributor.googleauthor | Kwon, Taeg Kyu | - |
dc.relation.code | 2009201698 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE & TECHNOLOGY[E] | - |
dc.sector.department | DIVISION OF MOLECULAR & LIFE SCIENCE | - |
dc.identifier.pid | younghan | - |
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