Increased Effect-Site Concentration of Propofol Reduces EC50 of Remifentanil for Successful Intubation Using the Shikani Optical Stylet without Neuromuscular Blockade
- Title
- Increased Effect-Site Concentration of Propofol Reduces EC50 of Remifentanil for Successful Intubation Using the Shikani Optical Stylet without Neuromuscular Blockade
- Author
- 전우재
- Keywords
- Propofol; Remifentanil; Intubation
- Issue Date
- 2019-12
- Publisher
- 순천향대 의학 연구소
- Citation
- Soonchunhyang Medical Science, v. 25, no. 2, page. 104-109
- Abstract
- Objective
For short-duration surgery, propofol and remifentanil are the drugs of choice for intubation without neuromuscular blockade. The Shikani Optical Stylet (SOS) is a novel semi-rigid type fiberoptic laryngoscope. In this study, we determined the clinically required effect-site concentration of remifentanil for intubation using SOS without neuromuscular blockade depending on propofol effect-site concentration.
Methods
We enrolled patients scheduled for elective surgery with general anesthesia, and assigned them into two groups by a randomized, double-blind method: concentration of propofol 3.5 μg/mL (group PRO 3.5) and 7.0 μg/mL (group PRO 7.0). Anesthesia was conducted with target-controlled infusion in predetermined target effect-site concentrations of propofol. The concentration of remifentanil for successful intubation using SOS in 50% of patients (EC50) was determined using a modified Dixon’s up-and-down method.
Results
The mean±standard deviation EC50 of remifentanil was 5.07±0.40 ng/mL in group PRO 3.5 and 1.79±0.44 ng/mL in group PRO 7.0. From probit analysis, EC50 and EC95 of remifentanil in group PRO 3.5 were 4.85 ng/mL (95% confidence interval [CI], 4.44–5.16 ng/mL) and 5.42 ng/mL (95% CI, 5.13–7.47 ng/mL) respectively, and EC50 and EC95 of remifentanil in group PRO 7.0 were 1.68 ng/mL (95% CI, 1.22–2.01 ng/mL) and 2.29 ng/mL (95% CI, 1.98–4.05 ng/mL), respectively.
Conclusion
Increased concentration of propofol reduced EC50 of remifentanil for successful intubation using SOS without neuromuscular blockade.
- URI
- https://jsms.sch.ac.kr/journal/view.php?doi=10.15746/sms.19.020https://repository.hanyang.ac.kr/handle/20.500.11754/157172
- ISSN
- 2233-4297; 2233-4289
- DOI
- 10.15746/sms.19.020
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
- Files in This Item:
- Increased Effect-Site Concentration of Propofol Reduces EC50 of Remifentanil.pdfDownload
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