Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 홍민하 | - |
dc.date.accessioned | 2020-11-17T08:03:30Z | - |
dc.date.available | 2020-11-17T08:03:30Z | - |
dc.date.issued | 2019-11 | - |
dc.identifier.citation | INTERNATIONAL NEUROUROLOGY JOURNAL, v. 23, page. 102-110 | en_US |
dc.identifier.issn | 2093-4777 | - |
dc.identifier.issn | 2093-6931 | - |
dc.identifier.uri | https://www.einj.org/journal/view.php?doi=10.5213/inj.1938216.108 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/155649 | - |
dc.description.abstract | Purpose: Hyperlipidemia, which promotes the development of atherosclerosis, ischemic stroke, and other forms of brain injury, can be induced by poloxamer-407. Berberine is a primary pharmacological active component of Coptidis Rhizoma that has a number of therapeutic activities. This study investigated the effects of berberine on poloxamer-407-induced brain inflammation by evaluating its effects on short-term memory, cell proliferation, inflammation, and apoptosis in the hippocampus. Methods: To induce hyperlipidemia in a rat model, 500 mg/kg of poloxamer-407 was injected intraperitoneally. Berberine was orally administered to the rats in the berberine-treated groups once a day for 4 weeks. The step-down task avoidance task was performed to measure short-term memory. An analysis of serum lipids, immunohistochemistry for 5-bromo-2'-deoxyuridine, glial fibrillary acidic protein (GAP), and ionized calcium-binding adapter molecule 1 (Ibal) in the dentate gyrus, and western blot analysis for Bax, Bcl-2, and cytochrome c in the hippocampus were performed. Results: In hyperlipidemic rats, berberine reduced the levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol and increased the level of high-density lipoprotein cholesterol in hyperlipidemic rats. Berberine also increased cell proliferation and short-term memory, as well as decreasing the expression of GFAP, Ibal, Bax, and cytochrorne c and increasing Bcl-2 expression. Conclusions: Berberine treatment improved short-term memory in hyperlipidemia by increasing neuronal proliferation and inhibiting neuronal apoptosis. Berberine treatment also improved lipid metabolism. | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN CONTINENCE SOC | en_US |
dc.subject | Hyperlipidemia | en_US |
dc.subject | Berberine | en_US |
dc.subject | Poloxamer | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Glial fibrillary acidic protein | en_US |
dc.subject | Ibal | en_US |
dc.title | Berberine Ameliorates Brain Inflammation in Poloxamer 407-Induced Hyperlipidemic Rats | en_US |
dc.type | Article | en_US |
dc.relation.volume | 23 | - |
dc.identifier.doi | 10.5213/inj.1938216.108 | - |
dc.relation.page | 102-110 | - |
dc.relation.journal | INTERNATIONAL NEUROUROLOGY JOURNAL | - |
dc.contributor.googleauthor | Kim, Mia | - |
dc.contributor.googleauthor | Kim, Tae-Woon | - |
dc.contributor.googleauthor | Kim, Chang-Ju | - |
dc.contributor.googleauthor | Shin, Mal-Soon | - |
dc.contributor.googleauthor | Hong, Minha | - |
dc.contributor.googleauthor | Park, Hye-Sang | - |
dc.contributor.googleauthor | Park, Sang-Seo | - |
dc.relation.code | 2019042889 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | minhahong | - |
dc.identifier.orcid | https://orcid.org/0000-0003-4924-1107 | - |
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