전염성 단핵구증의 임상 특성: 후향적 분석 연구

Abstract

Background and Objectives Infectious mononucleosis is mainly caused by Epstein-Barrvirus infection and it presents sore throat, fever, tonsillar enlargement with exudate, cervicallymphadenopathy, hepatosplenomegaly, and etc. Therefore, it is often misdiagnosed with acutetonsillitis. The aim of this study was to evaluate the clinical characteristics of patients with infectiousmononucleosis and recent changes. Subjects and Method From January 2008 to December 2017, we retrospectively studied 83patients who were diagnosed with infectious mononucleosis. We evaluated the patients’ clinicalcharacteristics such as sex, age, onset of disease, the department first visited, period of hospitalstay, symptoms, signs, the results of serologic test, and complications. Results Among 83 patients, 41 were male and 42 were female. The mean age was 16.1±7.28,with the oldest patient being 38 years old and the youngest patient being 2 years old. The proportionof patients older than 25 years was 10.8%. The most common symptom was sore throat(77%), followed by fever (67%), upper respiratory infection symptoms such as cough, sputum,rhinorrhea (37%), abdominal pain (16%), neck mass or neck pain (13%), and headache (4%). The most common sign was tonsillar enlargement (85%), followed by tonsillar white patch(68%), hepatosplenomegaly (67%), and cervical lymphadenopathy (60%). Complication occurredin 2 patients with mild jaundice, and there was no critical complication. The departmentpatients first visited was mostly otolaryngology (61%), followed by pediatrics (21%),gastroenterology (9%), and others (6%). Conclusion Patients with infectious mononucleosis mostly appeared to have fever, pharyngitisor cervical lymphadenitis, and the complication rate was low. The primary infection ageof infectious mononucleosis tended to increase in recent years. In adult patients, cervical lymphadenitiswas less, and white blood cell count and the proportion of lymphocyte was lowercompared to pediatric patients.