Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이경석 | - |
dc.date.accessioned | 2020-09-16T06:25:40Z | - |
dc.date.available | 2020-09-16T06:25:40Z | - |
dc.date.issued | 2019-10 | - |
dc.identifier.citation | INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, v. 180, no. 3, Page. 195-201 | en_US |
dc.identifier.issn | 1018-2438 | - |
dc.identifier.issn | 1423-0097 | - |
dc.identifier.uri | https://www.karger.com/Article/FullText/501224 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/153974 | - |
dc.description.abstract | Background: Previous studies have used serum periostin levels as a biomarker of Th2-driven inflammatory responses. However, no population-based study has yet examined the association of serum periostin levels with the allergic status of children. Objectives: The aim of this study was to determine the usefulness of periostin as a biomarker for allergy in a group of 7-year-old Korean children. Method: This prospective cross-sectional study examined 451 children (aged 7 years to 7 years and 11 months) from the general pediatric population who attended 6 different schools between June and July 2016. A total of 249 children, all of whom completed the questionnaire and skin prick test and provided blood samples, were included in the final analysis. Results: The geometric mean serum periostin level was 107.6 ng/mL (95% CI 104.5-110.7). After adjustment for confounding, serum periostin levels were significantly associated with sensitization to poly-allergens (adjusted odds ratio, aOR 1.032, 95% CI 1.006-1.059, p = 0.016) and pollen (aOR 1.020, 95% CI 1.002-1.039, p = 0.026). Serum periostin levels were also associated with eosinophil levels (adjusted beta = 0.023, SE = 0.009, p = 0.010), but were unrelated to body mass index, sex, obesity, or presence of an allergic disease. Conclusions: Our results suggest thatserum periostin level may have limited usefulness as a biomarker of allergic disease in children. | en_US |
dc.description.sponsorship | This study was supported by the Seongnam Atopy Project (SAP2016). Grant funding was provided by the Metropolis of Seongnam, and a Research Fund by the Soonchunhyang University, Korea. | en_US |
dc.language.iso | en | en_US |
dc.publisher | KARGER | en_US |
dc.subject | Allergen | en_US |
dc.subject | Pediatrics | en_US |
dc.subject | Periostin | en_US |
dc.subject | Polysensitization | en_US |
dc.title | Serum Periostin Level Has Limited Usefulness as a Biomarker for Allergic Disease in 7-Year-Old Children | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 180 | - |
dc.identifier.doi | 10.1159/000501224 | - |
dc.relation.page | 195-201 | - |
dc.relation.journal | INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | - |
dc.contributor.googleauthor | Sung, Myongsoon | - |
dc.contributor.googleauthor | Baek, Hey Sung | - |
dc.contributor.googleauthor | Yon, Dong Keon | - |
dc.contributor.googleauthor | Lee, Seung Won | - |
dc.contributor.googleauthor | Ha, Eun Kyo | - |
dc.contributor.googleauthor | Lee, Kyung Suk | - |
dc.contributor.googleauthor | Jee, Hye Mi | - |
dc.contributor.googleauthor | Sheen, Youn Ho | - |
dc.contributor.googleauthor | Ono, Junya | - |
dc.contributor.googleauthor | Izuhara, Kenji | - |
dc.relation.code | 2019002381 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | noquit | - |
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