Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 전대원 | - |
dc.date.accessioned | 2020-09-15T00:17:48Z | - |
dc.date.available | 2020-09-15T00:17:48Z | - |
dc.date.issued | 2019-10 | - |
dc.identifier.citation | PHARMACOLOGICAL RESEARCH, v. 148, article no. 104439 | en_US |
dc.identifier.issn | 1043-6618 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1043661819310734?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/153897 | - |
dc.description.abstract | The apoptosis alternate cell death pathways are extensively studied in recent years and their significance has been well recognized. With identification of newer cell death pathways, the therapeutic opportunities to modulate cell death have indeed further extended. Necroptosis, among other apoptosis alternate pathways, has been immensely studied recently in different hepatic disease models. Receptor-interacting protein 1 (RIPK1), RIPK3 and mixed lineage kinase domain like (MLKL) seemed to be the key players to mediate necroptosis pathway. Initially, necroptosis seemed to be following the typical pathway. But recently diverse pathways and outcomes have been observed. With recent studies reporting diverse outcomes, the necroptosis signalling has become a lot more interesting and intricate. The typical RIPK1 signalling followed by RIPK3 and MLKL might not always be strictly followed. Although, necroptosis signalling has been intensively investigated in various disease conditions; however, there is still a need to further elaborate and understand the unique scaffolding and kinase properties and other signalling interactions of necroptosis signalling molecules. | en_US |
dc.description.sponsorship | This work was supported by grants from the National Research Foundation of Korea (NRF), funded by the Korean Government (NRF-2017R1D1A3B04033457 and NRF-2017M3A9C8028794). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | en_US |
dc.subject | Necroptosis | en_US |
dc.subject | RIPK3 | en_US |
dc.subject | MLKL | en_US |
dc.title | Necroptosis signaling in liver diseases: An update | en_US |
dc.type | Article | en_US |
dc.relation.volume | 148 | - |
dc.identifier.doi | 10.1016/j.phrs.2019.104439 | - |
dc.relation.page | 1-12 | - |
dc.relation.journal | PHARMACOLOGICAL RESEARCH | - |
dc.contributor.googleauthor | Saeed, Waqar Khalid | - |
dc.contributor.googleauthor | Jun, Dae Won | - |
dc.contributor.googleauthor | Jang, Kiseok | - |
dc.contributor.googleauthor | Koh, Dong Hee | - |
dc.relation.code | 2019043858 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | noshin | - |
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