Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 명재경 | - |
dc.date.accessioned | 2020-08-27T01:43:04Z | - |
dc.date.available | 2020-08-27T01:43:04Z | - |
dc.date.issued | 2019-08 | - |
dc.identifier.citation | FRONTIERS IN PHARMACOLOGY, v. 10, article no. 892 | en_US |
dc.identifier.issn | 1663-9812 | - |
dc.identifier.uri | https://www.frontiersin.org/articles/10.3389/fphar.2019.00892/full | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/152627 | - |
dc.description.abstract | Background and Aims: Radiation-induced intestinal injury occurred in application of radiotherapy for abdominal and pelvic cancers or in nuclear accidents. Radiation-induced enteritis may be considered an ideal model of gastrointestinal inflammation. The endothelium is a crucial component of inflammation, and the endothelial dysfunction following radiation exposure induces the intestinal proinflammatory response and progression of radiation enteritis. Baicalein (5,6,7-trihydroxyflavonoid) is a flavonoid from Scutellaria baicalensis used in oriental herbal medicine. Baicalein has been found to have multiple beneficial properties including antioxidant, anti-inflammatory, anti-allergic, and anti-cancer activities. Here, we investigated the therapeutic effects of baicalein on endothelial dysfunction in radiation-induced intestinal inflammation. Materials and Methods: We performed histological analysis, bacterial translocation, and intestinal permeability assays and also assessed infiltration of leukocytes and inflammatory cytokine expression using a mouse model of radiation-induced enteritis. In addition, to investigate the effect of baicalein in endothelial dysfunction, we analyzed endothelial-derived adherent molecules in human umbilical vein endothelial cells (HUVECs) and irradiated intestinal tissue. Results: Histological damage such as shortening of villi length and impaired intestinal crypt function was observed in the radiation-induced enteritis mouse model. Intestinal damage was attenuated in baicalein-treated groups with improvement of intestinal barrier function. Baicalein inhibited the expression of radiation-induced adherent molecules in HUVECs and intestine of irradiated mouse and decreased leukocyte infiltration in the radiation-induced enteritis. Conclusions: Baicalein could accelerate crypt regeneration via recovery of endothelial damage. Therefore, baicalein has a therapeutic effect on radiation-induced intestinal inflammation by attenuating endothelial damage. | en_US |
dc.description.sponsorship | This study was supported by a grant from the Korea Institute of Radiological and Medical Sciences (KIRAMS), funded by the Ministry of Science and ICT (MSIT), Republic of Korea (No. 50535-2019). | en_US |
dc.language.iso | en | en_US |
dc.publisher | FRONTIERS MEDIA SA | en_US |
dc.subject | baicalein | en_US |
dc.subject | intestinal inflammation | en_US |
dc.subject | endothelial cells | en_US |
dc.subject | adherent molecules | en_US |
dc.subject | irradiation | en_US |
dc.title | Baicalein Mitigates Radiation-Induced Enteritis by Improving Endothelial Dysfunction | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.3389/fphar.2019.00892 | - |
dc.relation.journal | FRONTIERS IN PHARMACOLOGY | - |
dc.contributor.googleauthor | Jang, Hyosun | - |
dc.contributor.googleauthor | Lee, Janet | - |
dc.contributor.googleauthor | Park, Sunhoo | - |
dc.contributor.googleauthor | Kim, Joong Sun | - |
dc.contributor.googleauthor | Shim, Sehwan | - |
dc.contributor.googleauthor | Lee, Seung Bum | - |
dc.contributor.googleauthor | Han, Sung-Honn | - |
dc.contributor.googleauthor | Myung, Hyunwook | - |
dc.contributor.googleauthor | Kim, Hyewon | - |
dc.contributor.googleauthor | Myung, Jae Kyung | - |
dc.relation.code | 2019045002 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | tontos | - |
dc.identifier.researcherID | AAL-5497-2020 | - |
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