Rosai-Dorfman disease, also known as the sinus histiocytosis with massive lymphadenopathy,is a rare and benign histioproliferative disease in which lymphadenopathy results from infiltrationand dilatation of lymph node sinuses by large histiocytes. We experienced a case of a59-year-old man, presenting bilateral cervical masses with pain since one month ago. Radiologically,there were multiple enlarged lymph nodes with homogenous contrast enhancementat both cervical areas. Excisional biopsy revealed that the tumor was consistent with the Rosai-Dorfman disease. The patient was treated successfully with corticosteroid. Herein, we reportour experiences with literature reviews.