Implication of Egr-1 in trifluoperazine-induced growth inhibition in human U87MG glioma cells.
- Title
- Implication of Egr-1 in trifluoperazine-induced growth inhibition in human U87MG glioma cells.
- Author
- 이영한
- Keywords
- cell cycle; cyclin D1; glioma; trifluoperazine;; tumor suppressor proteins
- Issue Date
- 2004-08
- Publisher
- KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY
- Citation
- EXPERIMENTAL AND MOLECULAR MEDICINE, v. 36, No.4, Page. 380-386
- Abstract
- The early growth response gene-1 (Egr-1) is a
tumor suppressor which plays an important role in
cell growth, differentiation and apoptosis. Egr-1
has been shown to be down-regulated in many
types of tumor tissues. Trifluoperazine (TFP), a
phenothiazine class of antipsychotics, restored serum-induced Egr-1 expression in several cancer
cell lines. We investigated the effect of Egr-1
expression on the TFP-induced inhibition of cell
growth. Ectopic expression of Egr-1 enhanced the
TFP-induced antiproliferative activity and downregulated cyclin D1 level in U87MG glioma cells.
Our results suggest that antipsychotics TFP exhibits antiproliferative activity through up-regulation
of Egr-1.
- URI
- https://search.proquest.com/docview/1800522549?accountid=11283https://repository.hanyang.ac.kr/handle/20.500.11754/151582
- ISSN
- 12263613
- DOI
- 10.1038/emm.2004.50
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > ETC
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