헤파린이 결합된 PLGA 나노입자와 혈소판이 풍부한 혈장을 이용한 피부재생
- Title
- 헤파린이 결합된 PLGA 나노입자와 혈소판이 풍부한 혈장을 이용한 피부재생
- Other Titles
- Skin regeneration using platelet-rich plasma and heparin-conjugated PLGA nanospheres
- Author
- 안수정
- Advisor(s)
- 임태연
- Issue Date
- 2010-08
- Publisher
- 한양대학교
- Degree
- Master
- Abstract
- Platelet-rich plasma (PRP) is known to stimulate skin wound healing. In this study, we investigated whether long-term delivery of growth factors contained in PRP enhances skin regeneration as compared to short-term delivery. Heparin-conjugated poly(L-lactide-co-glycolide) nanospheres (HCPNs) were used as a vehicle for long-term delivery of growth factors contained in PRP. Fibrin gel, HCPN-loaded fibrin gel, PRP-loaded fibrin gel, and PRP-loaded HCPNs suspended in fibrin gel were implanted to full thickness skin defects of mice. The wound area was significantly reduced in group of PRP-loaded HCPNs suspended in fibrin gel compared to the other groups. Suprabasal cytokeratin differentiation in squamous neoepithelium was greatest in group of PRP-loaded HCPNs suspended in fibrin gel. This study demonstrates that a long-term delivery of growth factors contained in PRP enhances skin wound healing and neovascularization in neodermis.
- URI
- https://repository.hanyang.ac.kr/handle/20.500.11754/141516http://hanyang.dcollection.net/common/orgView/200000415593
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > BIOENGINEERING(생명공학과) > Theses (Master)
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