전자선 조사를 통한 생분해성고분자 나노섬유의 표면 개질
- Title
- 전자선 조사를 통한 생분해성고분자 나노섬유의 표면 개질
- Other Titles
- Surface modification of biodegradable polymer nanofibers by electron-beam irradiation
- Author
- 김우진
- Alternative Author(s)
- KIM, WOO JIN
- Advisor(s)
- 신흥수
- Issue Date
- 2012-02
- Publisher
- 한양대학교
- Degree
- Master
- Abstract
- The morphology of electrospun nanofiber sheet is similar with the structure of extracellular matrix (ECM) in composing native tissue. However, electrospun
nanofibers prepared with synthetic biodegradable polymer have some limitations in regulating adhesion, proliferation, and spreading of cells because of their surface hydrophobicity and absence of cell-interactive cues. In this study, we functionalized the electrospun poly(L-lactic acid) (PLLA) or poly(L-lactide-co-ε-caprolactone)
(PLCL) nanofibers with acrylic acid (AAc) to modulate their surface hydrophilicity using electron-beam irradiation method and then measured grafting ratio of AAc,
water contact angle, ATR-FTIR, and mechanical properties of AAc-grafted nanofibers. A grafting ratio of AAc on the nanofibers was increased as irradiation dose and AAc concentration were increased. AAc-grafted nanofibers also have higher wettability than non-modified nanofibers, and their wettability was easily controlled. In conclusion, those surface-modified nanofibers may be an essential candidate to control cell attachment in tissue engineering applications.
- URI
- https://repository.hanyang.ac.kr/handle/20.500.11754/137409http://hanyang.dcollection.net/common/orgView/200000419324
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > BIOENGINEERING(생명공학과) > Theses (Master)
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