Synthesis of Bioactive Indole via Cu-catalyzed Three-component Cyclization

Abstract

Indole derivatives synthesis has been recognized as important because of bioactivity. We developed three-component reaction that was a convenient and efficient one step reaction. This methodology has proved various for constructing indole derivatives from the corresponding diverse 2-ethynylaniline derivatives, triethyl orthoformate with methylene compounds. We will have bioactivity test and the indoles will are evaluated either usable or unusable.|인돌 유도체들은 그것들의 생리활성으로 인하여 합성적으로 중요하게 여겨지고 있다. 우리는 삼성분 축합반응을 사용하여 다양한 2-ethynyl-aniline유도체로 부터 인돌 화합물을 손쉬운 한단계의 반응으로 합성하는 방법을 개발 하였다. 이 방법을 이용하여 다양한 인돌 유도체를 합성하여 생리활성에 사용 가능한가의 여부를 제시하고자 한다.; Indole derivatives synthesis has been recognized as important because of bioactivity. We developed three-component reaction that was a convenient and efficient one step reaction. This methodology has proved various for constructing indole derivatives from the corresponding diverse 2-ethynylaniline derivatives, triethyl orthoformate with methylene compounds. We will have bioactivity test and the indoles will are evaluated either usable or unusable.