Activation of protein kinase B(Akt) signaling after electroconvulsive shock in the rat hippocampus.
- Title
- Activation of protein kinase B(Akt) signaling after electroconvulsive shock in the rat hippocampus.
- Author
- 이영한
- Keywords
- Akt; Electroconvulsive shock; Erk; Phosphatidylinositol 3-OH kinase; Rat hippocampus; Signal transduction
- Issue Date
- 2004-01
- Publisher
- Elsevier Inc.
- Citation
- Progress in Neuro-Psychopharmacology and Biological Psychiatry, v. 28, No. 1, Page. 41-44
- Abstract
- Akt (protein kinase B, PKB) is one of the major downstream pathways of neurotrophin signaling and plays important roles in the cell survival and synaptic plasticity of the central nervous system. Electroconvulsive shock (ECS) has neurotrophic effect and it affects the synaptic plasticity. It can activate another major pathway of neurotrophin signaling, i.e., Ras–Raf–MEK–Erk cascade. In this paper, the authors investigated whether ECS can activate Akt signaling in the rat hippocampus. After a single ECS, the phosphorylation of Akt was increased, as were the signals detected by phospho-PDK1 substrate antibody, which suggests the activation of PDK1, an upstream molecule of Akt. The phosphorylation of downstream molecules of Akt, forkhead transcription factors (FKHR), endothelial nitric oxide synthase (eNOS), and glycogen synthase kinase-3β (GSK-3β) was also increased. The increased phosphorylation of Akt appeared within 5 min of ECS and its time frame paralleled that of the phosphorylation of Erks. Taken together, these results suggest that ECS activates Akt signaling over a similar time scale to that of Erks in the rat hippocampus.
- URI
- https://www.sciencedirect.com/science/article/pii/S0278584603001738?via%3Dihub#!https://repository.hanyang.ac.kr/handle/20.500.11754/132996
- ISSN
- 0278-5846
- DOI
- 10.1016/S0278-5846(03)00173-8
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > ETC
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