HisCoM-GGI: Software for Hierarchical structural component analysis of gene-gene interactions
- Title
- HisCoM-GGI: Software for Hierarchical structural component analysis of gene-gene interactions
- Author
- 최성경
- Keywords
- gene-gene interactions; generalized structured component analysis; genome-wide association study; ridge regression
- Issue Date
- 2018-12
- Publisher
- 한국유전체학회
- Citation
- Genomics & Informatics, v. 16, No. 4, Article no. e38
- Abstract
- Gene-gene interaction (GGI) analysis is known to play an important role in explaining missing heritability. Many previous studies have already proposed software to analyze GGI, but most methods focus on a binary phenotype in a case-control design. In this study, we developed “Hierarchical structural CoMponent analysis of Gene-Gene Interactions” (HisCoM-GGI) software for GGI analysis with a continuous phenotype. The HisCoM-GGI method considers hierarchical structural relationships between genes and single nucleotide polymorphisms (SNPs), enabling both gene-level and SNP-level interaction analysis in a single model. Furthermore, this software accepts various types of genomic data and supports data management and multithreading to improve the efficiency of genome-wide association study data analysis. We expect that HisCoM-GGI software will provide advanced accessibility to researchers in genetic interaction studies and a more effective way to understand biological mechanisms of complex diseases.
- URI
- https://genominfo.org/journal/view.php?doi=10.5808/GI.2018.16.4.e38https://repository.hanyang.ac.kr/handle/20.500.11754/121474
- ISSN
- 2234-0742
- DOI
- 10.5808/GI.2018.16.4.e38
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > APPLIED MATHEMATICS(응용수학과) > Articles
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML