Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이민형 | - |
dc.date.accessioned | 2019-12-10T00:28:53Z | - |
dc.date.available | 2019-12-10T00:28:53Z | - |
dc.date.issued | 2018-11 | - |
dc.identifier.citation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v. 67, page. 284-292 | en_US |
dc.identifier.issn | 1226-086X | - |
dc.identifier.issn | 1876-794X | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1226086X18303319?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/120522 | - |
dc.description.abstract | Receptor for advanced glycation end-products (RAGE) is overexpressed in various cancer cells. In this study, a RAGE-binding peptide (RBP) was conjugated to polyethylenimine (25 kDa, PEI). RBP-conjugated PEI (PEI-RBP) was characterized as a dual-functional reagent, a RAGE-mediated gene carrier and an anti-angiogenic reagent. As a gene carrier, PEI-RBP had higher transfection efficiency to the C6 glioblastoma cells than PEI. As an anti-angiogenic reagent, the pEmpty/PEI-RBP complex reduced RAGE expression on the surface of the C6 glioblastoma cells. Also, the complex reduced the VEGF expression and tube formation of endothelial cells. Therefore, PEI-RBP may be useful for development of glioblastoma therapy. (C) 2018 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by the Bio & Medical Technology Development Program through NRF funded by the Ministry of Science and ICT (NRF-2016M3A9B4918833). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCIENCE INC | en_US |
dc.subject | Anti-angiogenesis | en_US |
dc.subject | Gene delivery | en_US |
dc.subject | Glioblastoma | en_US |
dc.subject | Polyethylenimine | en_US |
dc.subject | RAGE-binding peptide | en_US |
dc.title | RAGE-binding peptide-conjugated polyethylenimine as a dual-functional carrier: A RAGE-mediated gene carrier and an anti-angiogenic reagent | en_US |
dc.type | Article | en_US |
dc.relation.volume | 67 | - |
dc.identifier.doi | 10.1016/j.jiec.2018.06.040 | - |
dc.relation.page | 284-292 | - |
dc.relation.journal | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.contributor.googleauthor | Lee, Dahee | - |
dc.contributor.googleauthor | Choi, Eunji | - |
dc.contributor.googleauthor | Lee, Jaewon | - |
dc.contributor.googleauthor | Oh, Jungju | - |
dc.contributor.googleauthor | Lee, Seonyeong | - |
dc.contributor.googleauthor | Lee, Minhyung | - |
dc.relation.code | 2018007973 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | minhyung | - |
dc.identifier.orcid | http://orcid.org/0000-0002-7083-9296 | - |
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