TY - JOUR AU - 이민형 DA - 2018/11 PY - 2018 UR - https://www.sciencedirect.com/science/article/pii/S1226086X18303319?via%3Dihub UR - https://repository.hanyang.ac.kr/handle/20.500.11754/120522 AB - Receptor for advanced glycation end-products (RAGE) is overexpressed in various cancer cells. In this study, a RAGE-binding peptide (RBP) was conjugated to polyethylenimine (25 kDa, PEI). RBP-conjugated PEI (PEI-RBP) was characterized as a dual-functional reagent, a RAGE-mediated gene carrier and an anti-angiogenic reagent. As a gene carrier, PEI-RBP had higher transfection efficiency to the C6 glioblastoma cells than PEI. As an anti-angiogenic reagent, the pEmpty/PEI-RBP complex reduced RAGE expression on the surface of the C6 glioblastoma cells. Also, the complex reduced the VEGF expression and tube formation of endothelial cells. Therefore, PEI-RBP may be useful for development of glioblastoma therapy. (C) 2018 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. PB - ELSEVIER SCIENCE INC KW - Anti-angiogenesis KW - Gene delivery KW - Glioblastoma KW - Polyethylenimine KW - RAGE-binding peptide TI - RAGE-binding peptide-conjugated polyethylenimine as a dual-functional carrier: A RAGE-mediated gene carrier and an anti-angiogenic reagent VL - 67 DO - 10.1016/j.jiec.2018.06.040 T2 - JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY ER -