Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신인철 | - |
dc.date.accessioned | 2019-12-09T19:16:34Z | - |
dc.date.available | 2019-12-09T19:16:34Z | - |
dc.date.issued | 2018-10 | - |
dc.identifier.citation | BMB REPORTS, v. 51, no. 10, page. 486-492 | en_US |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.issn | 1976-670X | - |
dc.identifier.uri | http://www.bmbreports.org/journal/view.html?doi=10.5483/BMBRep.2018.51.10.192 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/120400 | - |
dc.description.abstract | The CCN protein family is composed of six matricellular proteins, which serve regulatory roles rather than structural roles in the extracellular matrix. First identified as secreted proteins which are induced by oncogenes, the acronym CCN came from the names of the first three members: CYR61, CTGF, and NOV. All six members of the CCN family consist of four cysteine-rich modular domains. CCN proteins are known to regulate cell adhesion, proliferation, differentiation, and apoptosis. In addition, CCN proteins are associated with cardiovascular and skeletal development, injury repair, inflammation, and cancer. They function either through binding to integrin receptors or by regulating the expression and activity of growth factors and cytokines. Given their diverse roles related to the pathology of certain diseases such as fibrosis, arthritis, atherosclerosis, diabetic nephropathy, retinopathy, and cancer, there are many emerging studies targeting CCN protein signaling pathways in attempts to elucidate their potentials as therapeutic targets. | en_US |
dc.description.sponsorship | This work was supported by an NRF grant (2016R1A2 B4011196) from the Korea Research Foundation and by the Bio & Medical Technology Development Program of the NRF funded by the Ministry of Science & ICT (No. 2017M3A9G 8084539). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | en_US |
dc.subject | Cancer | en_US |
dc.subject | CCN family | en_US |
dc.subject | Matricellular protein | en_US |
dc.subject | Signal transduction | en_US |
dc.subject | Therapeutic target | en_US |
dc.title | Role of the CCN protein family in cancer | en_US |
dc.type | Article | en_US |
dc.relation.no | 10 | - |
dc.relation.volume | 51 | - |
dc.identifier.doi | 10.5483/BMBRep.2018.51.10.192 | - |
dc.relation.page | 486-492 | - |
dc.relation.journal | BMB REPORTS | - |
dc.contributor.googleauthor | Kim, Hyungjoo | - |
dc.contributor.googleauthor | Son, Seogho | - |
dc.contributor.googleauthor | Shin, Incheol | - |
dc.relation.code | 2018010537 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | incheol | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.