신인철
2019-12-09T19:16:34Z
2019-12-09T19:16:34Z
2018-10
BMB REPORTS, v. 51, no. 10, page. 486-492
1976-6696
1976-670X
http://www.bmbreports.org/journal/view.html?doi=10.5483/BMBRep.2018.51.10.192
https://repository.hanyang.ac.kr/handle/20.500.11754/120400
The CCN protein family is composed of six matricellular proteins, which serve regulatory roles rather than structural roles in the extracellular matrix. First identified as secreted proteins which are induced by oncogenes, the acronym CCN came from the names of the first three members: CYR61, CTGF, and NOV. All six members of the CCN family consist of four cysteine-rich modular domains. CCN proteins are known to regulate cell adhesion, proliferation, differentiation, and apoptosis. In addition, CCN proteins are associated with cardiovascular and skeletal development, injury repair, inflammation, and cancer. They function either through binding to integrin receptors or by regulating the expression and activity of growth factors and cytokines. Given their diverse roles related to the pathology of certain diseases such as fibrosis, arthritis, atherosclerosis, diabetic nephropathy, retinopathy, and cancer, there are many emerging studies targeting CCN protein signaling pathways in attempts to elucidate their potentials as therapeutic targets.
This work was supported by an NRF grant (2016R1A2 B4011196) from the Korea Research Foundation and by the Bio & Medical Technology Development Program of the NRF funded by the Ministry of Science & ICT (No. 2017M3A9G 8084539).
en_US
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Cancer
CCN family
Matricellular protein
Signal transduction
Therapeutic target
Role of the CCN protein family in cancer
Article
10
51
10.5483/BMBRep.2018.51.10.192
486-492
BMB REPORTS
Kim, Hyungjoo
Son, Seogho
Shin, Incheol
2018010537
S
COLLEGE OF NATURAL SCIENCES[S]
DEPARTMENT OF LIFE SCIENCE
incheol