Precision medicine and drug development in Alzheimer's disease: the importance of sexual dimorphism and patient stratification
- Title
- Precision medicine and drug development in Alzheimer's disease: the importance of sexual dimorphism and patient stratification
- Author
- 김승현
- Keywords
- Alzheimer's disease; Biomarkers; Sex; Gender; Systems biology; Precision medicine; Precision pharmacology; Homeostasis; Sexual dimorphism; Clinical trials
- Issue Date
- 2018-06
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Citation
- FRONTIERS IN NEUROENDOCRINOLOGY, v. 50, page. 31-51
- Abstract
- Neurodegenerative diseases (ND) are among the leading causes of disability and mortality. Considerable sex differences exist in the occurrence of the various manifestations leading to cognitive decline. Alzheimer's disease (AD) exhibits substantial sexual dimorphisms and disproportionately affects women. Women have a higher life expectancy compared to men and, consequently, have more lifespan to develop AD. The emerging precision medicine and pharmacology concepts taking into account the individual genetic and biological variability relevant for disease risk, prevention, detection, diagnosis, and treatment are expected to substantially enhance our knowledge and management of AD. Stratifying the affected individuals by sex and gender is an important basic step towards personalization of scientific research, drug development, and care.We hypothesize that sex and gender differences, extending from genetic to psychosocial domains, are highly relevant for the understanding of AD pathophysiology, and for the conceptualization of basic/translational research and for clinical therapy trial design.
- URI
- https://www.sciencedirect.com/science/article/pii/S0091302218300487?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/119074
- ISSN
- 0091-3022; 1095-6808
- DOI
- 10.1016/j.yfrne.2018.06.001
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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