Proliferation of prostate epithelia induced by IL-6 from stroma reacted with Trichomonasvaginalis
- Title
- Proliferation of prostate epithelia induced by IL-6 from stroma reacted with Trichomonasvaginalis
- Author
- 류재숙
- Keywords
- cytokines; inflammation; prostatic hyperplasia; protozoan infections
- Issue Date
- 2018-06
- Publisher
- WILEY
- Citation
- PARASITE IMMUNOLOGY, v. 40, no. 6, Article no. e12531
- Abstract
- Benign prostatic hyperplasia (BPH) is characterized by the proliferation of stromal and epithelial cell types in the prostate, and interactions between the two types of cells. We demonstrated previously that proliferation of prostate stromal cells was induced by BPH epithelial cells in response to Trichomonasvaginalis (Tv) infection via crosstalk with mast cells. In this study, we investigated whether IL-6 released by the proliferating stromal cells in turn induce the BPH epithelial cells to multiply. When culture supernatants of the proliferating prostate stromal cells were added to BPH epithelial cells, the latter multiplied, and expression of cyclin D1, FGF2 and Bcl-2 increased. Blocking the IL-6 signalling pathway with anti-IL-6R antibody or JAK1/2 inhibitor inhibited the proliferation of the BPH epithelial cells and reduced the expression of IL-6, IL-6R and STAT3. Also, epithelial-mesenchymal transition was detected in the proliferating BPH epithelial cells. In conclusion, IL-6 released from proliferating prostate stromal cells induced by BPH epithelial cells infected with Tv in turn induces multiplication of the BPH epithelial cells. This result provides first evidence that the inflammatory microenvironment of prostate stromal cells resulting from Tv infection induces the proliferation of prostate epithelial cells by stromal-epithelial interaction.
- URI
- https://onlinelibrary.wiley.com/doi/abs/10.1111/pim.12531https://repository.hanyang.ac.kr/handle/20.500.11754/118993
- ISSN
- 0141-9838; 1365-3024
- DOI
- 10.1111/pim.12531
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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