Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이현 | - |
dc.date.accessioned | 2019-12-08T01:40:17Z | - |
dc.date.available | 2019-12-08T01:40:17Z | - |
dc.date.issued | 2018-05 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v. 8, Article no. 7691 | en_US |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://www.nature.com/articles/s41598-018-25800-2 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/118630 | - |
dc.description.abstract | In-depth molecular pathogenesis of ground-glass nodular lung adenocarcinoma has not been well understood. The objectives of this study were to identify genomic alterations in ground-glass nodular lung adenocarcinomas and to investigate whether viral transcripts were detected in these tumors. Nine patients with pure (n = 4) and part-solid (n = 5) ground-glass nodular adenocarcinomas were included. Six were females with a median age of 58 years. We performed targeted exon sequencing and RNA sequencing. EGFR (n = 10), IDH2 (n = 2), TP53 (n = 1), PTEN (n = 1), EPHB4 (n = 1), and BRAF (n = 1) were identified as driver mutations by targeted exon sequencing. Vasculogenesis-associated genes including NOTCH4 and TGFBR3 expression were significantly downregulated in adenocarcinoma tissue versus normal tissue (adjusted P values < 0.001 for both NOTCH4 and TGFBR3). In addition, five novel fusion gene loci were identified in four lung adenocarcinomas. However, no significant virus-associated transcripts were detected in tumors. In conclusions, EGFR, IDH2, TP53, PTEN, EPHB4, and BRAF were identified as putative driver mutations of ground-glass nodular adenocarcinomas. Five novel fusion genes were also identified in four tumors. Viruses do not appear to be involved in the tumorigenesis of ground-glass nodular lung adenocarcinoma. | en_US |
dc.description.sponsorship | This study was supported by grants from Korean Foundation for Cancer Research (KFCR-CB-2011-09-083). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | INTERNATIONAL-ASSOCIATION | en_US |
dc.subject | PROGNOSTIC VALUE | en_US |
dc.subject | BREAST-CANCER | en_US |
dc.subject | CT | en_US |
dc.subject | MUTATIONS | en_US |
dc.subject | OPACITY | en_US |
dc.subject | PTEN | en_US |
dc.subject | BRAF | en_US |
dc.subject | EPIDEMIOLOGY | en_US |
dc.subject | SURVIVAL | en_US |
dc.title | Genomic alterations of ground-glass nodular lung adenocarcinoma | en_US |
dc.type | Article | en_US |
dc.relation.volume | 8 | - |
dc.identifier.doi | 10.1038/s41598-018-25800-2 | - |
dc.relation.page | 1-9 | - |
dc.relation.journal | SCIENTIFIC REPORTS | - |
dc.contributor.googleauthor | Lee, Hyun | - |
dc.contributor.googleauthor | Joung, Je-Gun | - |
dc.contributor.googleauthor | Shin, Hyun-Tae | - |
dc.contributor.googleauthor | Kim, Duk-Hwan | - |
dc.contributor.googleauthor | Kim, Yujin | - |
dc.contributor.googleauthor | Kim, Hojoong | - |
dc.contributor.googleauthor | Kwon, O. Jung | - |
dc.contributor.googleauthor | Shim, Young Mog | - |
dc.contributor.googleauthor | Lee, Ho Yun | - |
dc.contributor.googleauthor | Lee, Kyung Soo | - |
dc.relation.code | 2018003596 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | namuhanayeyo | - |
dc.identifier.researcherID | G-1336-2018 | - |
dc.identifier.orcid | http://orcid.org/0000-0002-1269-0913 | - |
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