Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김용주 | - |
dc.date.accessioned | 2019-12-08T01:11:59Z | - |
dc.date.available | 2019-12-08T01:11:59Z | - |
dc.date.issued | 2018-05 | - |
dc.identifier.citation | JOURNAL OF KOREAN MEDICAL SCIENCE, v. 33, no. 21, Article no. UNSP e102 | en_US |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.issn | 1598-6357 | - |
dc.identifier.uri | https://jkms.org/DOIx.php?id=10.3346/jkms.2018.33.e102 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/118598 | - |
dc.description.abstract | Background: This study was performed to assess serial cytokine changes and their clinical impact in children with cerebral palsy (CP) who received granulocyte-colony stimulating factor (G-CSF) followed by infusion of autologous mobilized peripheral blood mononuclear cells (mPBMC5).Methods: Peripheral blood (PB) samples were collected from 16 CP children at enrollment, and 1 month and 7 months after G-CSF infusion as well as at the end of the study. Cytokine levels were measured by enzyme-linked immunosorbent assays with plasma samples.Results: There were no significant differences in cytokine levels between the mPBMC and placebo groups over 6 months. However, when clinical responders and non-responders were compared, interleukin (IL)-6 (P= 0.050) as well as G-CSF (P= 0.010) were higher in the responders than the non-responders at 1 month, while brain-derived neurotrophic factor (BDNF) (P= 0.030) and insulin-like growth factor (IGF)-1 (P= 0.001) were lower. In addition, BDNF was higher at baseline in the responders than the non-responders (P= 0.030).Conclusion: The changes of G-CSF itself, as well as G-CSF-induced cytokines such as IL-6, may be associated with the clinical improvement of neurologic functions. The G-CSF-induced changes of IL-6, BDNF and IGF-1, and BDNF levels before treatment, could be used as prognostic factors in G-CSF trials in CP children. | en_US |
dc.description.sponsorship | This work was supported by the Research Fund of Hanyang University (HY-2014). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | en_US |
dc.subject | Cytokines | en_US |
dc.subject | Granulocyte-colony Stimulating Factor (G-CSF) | en_US |
dc.subject | Peripheral Blood Mononuclear Cells | en_US |
dc.subject | Cerebral Palsy | en_US |
dc.title | Serial Changes of Cytokines in Children with Cerebral Palsy Who Received Intravenous Granulocyte-colony Stimulating Factor Followed by Autologous Mobilized Peripheral Blood Mononuclear Cells | en_US |
dc.type | Article | en_US |
dc.relation.no | 21 | - |
dc.relation.volume | 33 | - |
dc.identifier.doi | 10.3346/jkms.2018.33.e102 | - |
dc.relation.page | 1-1 | - |
dc.relation.journal | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.contributor.googleauthor | Koh, Hani | - |
dc.contributor.googleauthor | Rah, Wee-Jin | - |
dc.contributor.googleauthor | Kim, Yong-Joo | - |
dc.contributor.googleauthor | Moon, Jin-Hwa | - |
dc.contributor.googleauthor | Kim, Mi-Jung | - |
dc.contributor.googleauthor | Lee, Young-Ho | - |
dc.relation.code | 2018003141 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kyjoo | - |
dc.identifier.orcid | https://orcid.org/0000-0002-2654-5397 | - |
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