Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2019-12-05T15:02:38Z | - |
dc.date.available | 2019-12-05T15:02:38Z | - |
dc.date.issued | 2018-02 | - |
dc.identifier.citation | LUPUS, v. 27, no. 2, page. 235-242 | en_US |
dc.identifier.issn | 0961-2033 | - |
dc.identifier.issn | 1477-0962 | - |
dc.identifier.uri | https://journals.sagepub.com/doi/abs/10.1177/0961203317716789?journalCode=lupa | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/117589 | - |
dc.description.abstract | Objective The objective of this paper is to investigate the clinical characteristics and prognosis of patients with late-onset systemic lupus erythematosus (SLE) using a prospective observational cohort.Methods Late-onset SLE (50 years old) was compared with adult-onset SLE (18 and <50 years old) using 1997 ACR classification criteria for SLE, autoantibodies, disease activity measured by Adjusted Mean SLE Disease Activity Index (AMS), and damage measured by Systemic Lupus International Collaborating Clinics/ACR Damage Index (SDI). The standardized mortality ratio (SMR) was calculated.Results A total of 917 patients with SLE were enrolled. The mean number of cumulative ACR criteria in late-onset SLE (n=32, 3.5%) was lower than that in adult-onset SLE (4.61.2 vs. 5.5 +/- 1.4, p<0.05). The percentage of patients with low complement was lower in late-onset SLE than adult-onset SLE (p<0.05). AMS was also lower in late-onset SLE (2.7 +/- 2.1 vs. 4.3 +/- 2.6, p<0.01), but SDI was similar between the two groups (50% vs. 43.4%, p=0.58). The SMR of late-onset SLE was 1.58 (95% CI 0.58-3.43), while the SMR of adult-onset SLE was 3.34 (2.34-4.63).Conclusion Compared with adult-onset SLE, late-onset SLE has a lower number of ACR criteria and lower disease activity. Organ damage is not different, but prognosis and mortality are more favorable. | en_US |
dc.description.sponsorship | The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported in part by an unrestricted grant (Hanyang University 201600000001387). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | SAGE PUBLICATIONS LTD | en_US |
dc.subject | Systemic lupus erythematosus | en_US |
dc.subject | late-onset | en_US |
dc.subject | prognosis | en_US |
dc.title | Late-onset systemic lupus erythematosus: Is it "mild lupus"? | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 27 | - |
dc.identifier.doi | 10.1177/0961203317716789 | - |
dc.relation.page | 235-242 | - |
dc.relation.journal | LUPUS | - |
dc.contributor.googleauthor | Sohn, I. W. | - |
dc.contributor.googleauthor | Joo, Y. B. | - |
dc.contributor.googleauthor | Won, S. | - |
dc.contributor.googleauthor | Bae, S. C. | - |
dc.relation.code | 2018003705 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
dc.identifier.orcid | http://orcid.org/0000-0003-4658-1093 | - |
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