Efficacy and safety of etomidate-based sedation compared with propofol-based sedation during ERCP in low-risk patients: a double-blind, randomized, noninferiority trial
- Title
- Efficacy and safety of etomidate-based sedation compared with propofol-based sedation during ERCP in low-risk patients: a double-blind, randomized, noninferiority trial
- Author
- 박찬혁
- Keywords
- ENDOSCOPIC PROCEDURES; EMERGENCY-DEPARTMENT; CLINICAL-TRIAL; PROCEDURAL SEDATION; GENERAL-ANESTHESIA; GI ENDOSCOPY; INDUCTION; COLONOSCOPY; INTUBATION; RESPONSES
- Issue Date
- 2018-01
- Publisher
- MOSBY-ELSEVIER
- Citation
- GASTROINTESTINAL ENDOSCOPY, v. 87, no. 1, page. 174-184
- Abstract
- Background and Aims: Etomidate is a short-acting intravenous hypnotic with a safety profile that is superior to alternative drugs such as propofol. However, there is a lack of evidence on the safety of etomidate in ERCP. The objective of this study was to compare efficacy and safety profiles of etomidate and propofol for endoscopic sedation.Methods: This single-center, randomized, double-blind, noninferiority trial included patients with American Society of Anesthesiologists (ASA) physical status I to II who had been scheduled for ERCP. All patients received.05 mg/kg midazolam intravenously as pretreatment before receiving etomidate or propofol. Either etomidate or propofol was then administered according to group allocation. The primary endpoint was an overall respiratory event. A noninferiority margin of 10% was assumed.Results: Sixty-three and 64 patients were enrolled in the etomidate and propofol groups, respectively. Respiratory events were identified in 10 patients (15.6%) in the etomidate group and 16 patients (25.4%) on the propofol group, with a rate difference of -9.8% (1-sided 97.5% confidence interval, -N to 4.2%). The overall incidence of cardiovascular events tended to be higher in the etomidate group (67.2% vs 50.8%, P Z.060). In particular, tachycardia (heart rate > 100 beats/min) was more common in the etomidate group than in the propofol group (64.1% vs 34.9%, P Z.001). Transient hypotension tended to be less common in the etomidate group (6.3 vs 15.9%, P Z.084).Conclusions: Etomidate-based sedation during ERCP was noninferior to propofol-based sedation in terms of the overall incidence of respiratory events in patients with ASA physical status I to II.
- URI
- https://www.giejournal.org/article/S0016-5107(17)32008-4/fulltexthttps://repository.hanyang.ac.kr/handle/20.500.11754/117268
- ISSN
- 0016-5107; 1097-6779
- DOI
- 10.1016/j.gie.2017.05.050
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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