Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이영열 | - |
dc.date.accessioned | 2019-12-03T04:22:10Z | - |
dc.date.available | 2019-12-03T04:22:10Z | - |
dc.date.issued | 2017-12 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF ONCOLOGY, v. 51, no. 6, page. 1739-1746 | en_US |
dc.identifier.issn | 1019-6439 | - |
dc.identifier.issn | 1791-2423 | - |
dc.identifier.uri | https://www.spandidos-publications.com/10.3892/ijo.2017.4161 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/116762 | - |
dc.description.abstract | KML001 (sodium metaarsenite; NaAs2O3) is known to have antitumor activity against a variety of cancers. In this study, we examined its effect on multiple myeloma (MM). KML001 reduced the growth of all MM cell lines examined with an IC50 of 5x10(-8) M. Exposure to KML001 (5x10(-8) M) decreased levels of cyclins A/B1/D1/E1, CDK2/4/6 in U266 cells and increased the p21 and p27 levels. Furthermore, p21 became bound to CDK2/4/6, resulting in a reduction of CDK2/4/6 kinase activity. The cleaved forms of Bcl-2, and caspases-3, -8 and -9 were detected, and the anti-apoptotic molecule, Bax, also increased. Activation of STAT1/3, NF-kappa B (p65 and p50 subunits), pAKT and pERK decreased, and p-PTEN increased. There was also a significant reduction of hTERT at 12 h and upregulation of gamma-H(2)A(X) and CHK1/2 molecules at 24 h. Thus, KML001 appears to have antitumor activity against MM by inhibiting various oncogenic signaling pathways. It may be useful for treating MM. | en_US |
dc.description.sponsorship | This study was conducted in the Hanyang University Hospital Clinical Laboratory, and this study was supported by Komipharm International Co., Ltd., Gyeonggi-do, Korea. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | SPANDIDOS PUBL LTD | en_US |
dc.subject | multiple myeloma | en_US |
dc.subject | KML001 | en_US |
dc.subject | cell cycle | en_US |
dc.subject | cell signaling | en_US |
dc.subject | telomere | en_US |
dc.title | Antitumoral effect of arsenic compound, sodium metaarsenite (KML001), on multiple myeloma cells | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 51 | - |
dc.identifier.doi | 10.3892/ijo.2017.4161 | - |
dc.relation.page | 1739-1746 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF ONCOLOGY | - |
dc.contributor.googleauthor | Kim, Seo Ju | - |
dc.contributor.googleauthor | Kim, Eun Shil | - |
dc.contributor.googleauthor | Kim, Sujong | - |
dc.contributor.googleauthor | Uhm, Jieun | - |
dc.contributor.googleauthor | Won, Young Woong | - |
dc.contributor.googleauthor | Park, Byeong Bae | - |
dc.contributor.googleauthor | Choi, Jung Hye | - |
dc.contributor.googleauthor | Lee, Young Yiul | - |
dc.relation.code | 2017001068 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | leeyy | - |
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