Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2019-11-26T04:50:58Z | - |
dc.date.available | 2019-11-26T04:50:58Z | - |
dc.date.issued | 2017-06 | - |
dc.identifier.citation | POSTGRADUATE MEDICINE, v. 129, no. 5, page. 531-537 | en_US |
dc.identifier.issn | 0032-5481 | - |
dc.identifier.issn | 1941-9260 | - |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.1080/00325481.2017.1319729 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/114540 | - |
dc.description.abstract | Objective: We evaluated the relationship between calprotectin levels and rheumatoid arthritis (RA), and the correlation between plasma/serum calprotectin and RA activity.Methods: We searched PUBMED, EMBASE, and Cochrane databases and performed meta-analyses comparing plasma/serum or synovial fluid calprotectin levels in RA patients and controls, and correlation coefficients between calprotectin levels and disease activity for 28 joints (DAS28) as well as C-reactive protein (CRP) in RA patients.Results: Sixteen studies including 849 RA patients and 266 controls were available for meta-analysis. Meta-analysis showed that calprotectin levels were significantly higher in the RA group than in the control group (SMD = 2.337, 95% CI = 1.544-3.130, p < 1.0x10(-8)). Stratification by rheumatoid factor (RF) status revealed significantly elevated calprotectin levels in the RF-positive RA group compared to that of the RF-negative RA group (SMD = 0.574, 95% CI = 0.345-0.804, p = 9.2x10(-7)). Meta-analysis of correlation coefficients identified a significant positive correlation between calprotectin levels and CRP or DAS28 (correlation coefficient for CRP = 0.566, 95% CI = 0.512-0.615, p < 1.0x10(-8); correlation coefficient for DAS28 = 0.438, 95% CI = 0.269-0.518, p = 2.5x10(-6)). Calprotectin levels in synovial fluid were significantly higher in the RA group than in the control group (SMD = 2.891, 95% CI = 1.067-4.715, p = 0.002).Conclusions: Our meta-analysis demonstrates that circulating and synovial fluid calprotectin levels are high in patients with RA, and that circulating calprotectin levels positively correlate with RA activity. | en_US |
dc.description.sponsorship | This study was supported in part by a grant of the Korea Healthcare Technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI15C2958). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | TAYLOR & FRANCIS LTD | en_US |
dc.subject | Calprotectin | en_US |
dc.subject | rheumatoid arthritis | en_US |
dc.subject | activity | en_US |
dc.title | Calprotectin levels in rheumatoid arthritis and their correlation with disease activity: a meta-analysis | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 129 | - |
dc.identifier.doi | 10.1080/00325481.2017.1319729 | - |
dc.relation.page | 531-537 | - |
dc.relation.journal | POSTGRADUATE MEDICINE | - |
dc.contributor.googleauthor | Bae, Sang-Cheol | - |
dc.contributor.googleauthor | Lee, Young Ho | - |
dc.relation.code | 2017001443 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
dc.identifier.orcid | http://orcid.org/0000-0003-4658-1093 | - |
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