Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 민경환 | - |
dc.date.accessioned | 2019-11-25T07:15:15Z | - |
dc.date.available | 2019-11-25T07:15:15Z | - |
dc.date.issued | 2017-05 | - |
dc.identifier.citation | PATHOBIOLOGY, v. 84, no. 3, page. 130-138 | en_US |
dc.identifier.issn | 1015-2008 | - |
dc.identifier.issn | 1423-0291 | - |
dc.identifier.uri | https://www.karger.com/Article/FullText/449428 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/114201 | - |
dc.description.abstract | Background: Smad4 and GATA3 proteins are known prognostic markers in various cancers. Smad4 is a mediator linked to both tumour suppression and progression. GATA3 is a regulator of development and morphogenesis of the mammary gland. We assessed and compared the predictive performance of Smad4 and GATA3 for clinical outcomes in patients with breast cancer. Methods: The combined expression pattern based on Smad4+/- and GATA3+/- was evaluated by immunostaining using breast cancer tissue microarray, and the relationships between protein expression and clinicopathological variables were analysed. Results: Smad4 expression was only associated with an ill-defined tumour border, whereas GATA3 was associated with several good prognostic factors. On analysis of combined markers, there was a significant difference in the expression of fascin (an important factor for cancer invasiveness) between the Smad4+/GATA3- and Smad4-/GATA3+ groups. Smad4+/GATA3- was correlated with worse clinicopathological parameters, relapse-free survival (RFS), and overall survival (OS), compared to Smad4-/GATA3+. Conclusion: Combined markers of Smad4/GATA3 showed a superior performance compared to single markers for predicting RFS and OS in patients with breast cancer. (C) 2017 S. Karger AG, Basel | en_US |
dc.description.sponsorship | This work was supported by Medical Research Funds from Kangbuk Samsung Hospital (No. HIY0150051). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | KARGER | en_US |
dc.subject | Smad4 protein | en_US |
dc.subject | GATA3 protein | en_US |
dc.subject | Prognosis | en_US |
dc.subject | Breast cancer | en_US |
dc.title | Expression pattern of Smad4/GATA3 as a predictor of survival in invasive ductal carcinoma of the breast | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 84 | - |
dc.identifier.doi | 10.1159/000449428 | - |
dc.relation.page | 130-138 | - |
dc.relation.journal | PATHOBIOLOGY | - |
dc.contributor.googleauthor | Min, Kyueng-Whan | - |
dc.contributor.googleauthor | Kim, Dong-Hoon | - |
dc.contributor.googleauthor | Do, Sung-Im | - |
dc.contributor.googleauthor | Chae, Seoung Wan | - |
dc.contributor.googleauthor | Kim, Kyungeun | - |
dc.contributor.googleauthor | Sohn, Jin Hee | - |
dc.contributor.googleauthor | Lee, Hyun Joo | - |
dc.contributor.googleauthor | Do, In-Gu | - |
dc.contributor.googleauthor | Pyo, Jung-Soo | - |
dc.contributor.googleauthor | Kim, Yuil | - |
dc.relation.code | 2017002049 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kyueng | - |
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