Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김유진 | - |
dc.date.accessioned | 2019-11-25T04:48:45Z | - |
dc.date.available | 2019-11-25T04:48:45Z | - |
dc.date.issued | 2017-05 | - |
dc.identifier.citation | NEUROSCIENCE LETTERS, v. 649, page. 20-27 | en_US |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.issn | 1872-7972 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0304394017303026?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/114077 | - |
dc.description.abstract | Dexmedetomidine (DXM) has anti-inflammatory effects, which is considered an important mechanism of DXM-induced neuroprotection from cerebral ischemia/reperfusion injury. We determined whether the anti-inflammatory effects of DXM are associated with inhibition of the toll-like receptor (TLR)-4/nuclear factor kappa B (NF-kappa B) pathway in a rat model of transient global cerebral ischemia/reperfusion injury. Fifty rats were randomly assigned to one of five groups (10 rats/group): Group S received no treatment; Group C underwent transient global ischemia (10 min); Group D received DXM 30 min before ischemia; Group R received resatorvid, a selective TLR-4 antagonist, 30 min before ischemia; and Group RD received resatorvid and DXM 30 min before ischemia. The numbers of necrotic and apoptotic cells and the levels of TLR-4, NF-kappa B, and caspase-3 were assessed 1 day after ischemia, and pro-inflammatory cytokines including tumor necrosis factor alpha (INF-alpha), interleukin 1 beta (IL-1 beta),and interleukin 6 (IL-6) were measured before ischemia and 2, 6, and 24 h thereafter. The necrotic and apoptotic cell counts and levels of TLR-4, NF-kappa B, and caspase-3 were higher in Group C than in other groups. TNF-alpha were higher in Group C than in other groups 2 h after ischemia, whereas IL-6 were higher in Group C6 h after ischemia. IL-1 beta was higher in Group C than in Group D 6 and 24 h after ischemia. Our findings suggest that the anti-inflammatory action of DXM via inactivation of the TLR-4/NF-kappa B pathway, in part, may explain DXM-induced neuroprotection after cerebral ischemia. (C) 2017 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | This research was supported by grant (No. KSA-2015-80020150468) from the Korean Society of Anesthesiologists. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER IRELAND LTD | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Dexmedetomidine | en_US |
dc.subject | Neuroprotection | en_US |
dc.subject | TLR-4 | en_US |
dc.subject | NF-kappa B | en_US |
dc.title | Dexmedetomidine confers neuroprotection against transient global cerebral ischemia/reperfusion injury in rats by inhibiting inflammation through inactivation of the TLR-4/NF-κB pathway | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.neulet.2017.04.011 | - |
dc.relation.journal | NEUROSCIENCE LETTERS | - |
dc.contributor.googleauthor | Kim, Eugene | - |
dc.contributor.googleauthor | Kim, Hyun-Chang | - |
dc.contributor.googleauthor | Lee, Seungmi | - |
dc.contributor.googleauthor | Ryu, Ho-Geol | - |
dc.contributor.googleauthor | Park, Yong-Hee | - |
dc.contributor.googleauthor | Kim, Jun Hyun | - |
dc.contributor.googleauthor | Lim, Young-Jin | - |
dc.contributor.googleauthor | Park, Hee-Pyoung | - |
dc.relation.code | 2017000590 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | emil7882 | - |
dc.identifier.researcherID | E-2446-2019 | - |
dc.identifier.orcid | http://orcid.org/0000-0002-1926-4191 | - |
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