Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 손현 | - |
dc.date.accessioned | 2019-11-25T04:19:00Z | - |
dc.date.available | 2019-11-25T04:19:00Z | - |
dc.date.issued | 2017-05 | - |
dc.identifier.citation | MOLECULES AND CELLS, v. 40, no. 7, page. 485-494 | en_US |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.issn | 0219-1032 | - |
dc.identifier.uri | http://www.molcells.org/journal/view.html?doi=10.14348/molcells.2017.0034 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/114050 | - |
dc.description.abstract | Oleanolic acid (OA) has neurotrophic effects on neurons, although its use as a neurological drug requires further research. In the present study, we investigated the effects of OA and OA derivatives on the neuronal differentiation of rat hippocampal neural progenitor cells. In addition, we investigated whether the class II histone deacetylase (HDAC) 5 mediates the gene expression induced by OA. We found that OA and OA derivatives induced the formation of neurite spines and the expression of synapse-related molecules. OA and OA derivatives stimulated HDAC5 phosphorylation, and concurrently the nuclear export of HDCA5 and the expression of HDAC5 target genes, indicating that OA and OA derivatives induce neural differentiation and synapse formation via a pathway that involves HDAC5 phosphorylation. | en_US |
dc.description.sponsorship | This research was supported by a National Research Foundation of Korea (NRF) grant (No. 2016R1A2B2006474) funded by the Ministry of Education, Science and Technology (MEST), Republic of Korea and the research fund of Hanyang University(HY-2017) awarded to HS. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | en_US |
dc.subject | HDAC5 | en_US |
dc.subject | neuronal differentiation | en_US |
dc.subject | oleanolic acid | en_US |
dc.title | Oleanolic Acid Promotes Neuronal Differentiation and Histone Deacetylase 5 Phosphorylation in Rat Hippocampal Neurons | en_US |
dc.type | Article | en_US |
dc.relation.no | 7 | - |
dc.relation.volume | 40 | - |
dc.identifier.doi | 10.14348/molcells.2017.0034 | - |
dc.relation.page | 485-494 | - |
dc.relation.journal | MOLECULES AND CELLS | - |
dc.contributor.googleauthor | Jo, Hye-Ryeong | - |
dc.contributor.googleauthor | Wang, Sung Eun | - |
dc.contributor.googleauthor | Kim, Yong-Seok | - |
dc.contributor.googleauthor | Lee, Chang Ho | - |
dc.contributor.googleauthor | Son, Hyeon | - |
dc.relation.code | 2017002526 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hyeonson | - |
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