Hollow hyaluronic acid particles by competition between adhesive and cohesive properties of catechol for anticancer drug carrier
- Title
- Hollow hyaluronic acid particles by competition between adhesive and cohesive properties of catechol for anticancer drug carrier
- Author
- 이수재
- Keywords
- Hyaluronic acid; Catechol; Redox transition; Adhesive; pH triggered release
- Issue Date
- 2017-05
- Publisher
- ELSEVIER SCI LTD
- Citation
- CARBOHYDRATE POLYMERS, v. 164, page. 309-316
- Abstract
- The marine mussel-inspired properties of catechol, adhesiveness and cohesiveness, have been applied with pH control to fabricate hollow particles using a silica core and catechol-modified hyaluronic acid (HA-CA) shell for an anticancer drug carrier. The competition between adhesive and cohesive properties of catechol with different pH values leads to various structures, a rough catechol modified HA (HA-CA) shell at pH 5.5, monodisperse spherical silica@HA-CA particles at pH 7.4, and an amorphous HA-CA layer at pH 8.5. The redox transition of catechol with pH is a key factor modulating the behavior of the HA-CA shell on the silica core, which induces strong adhesion of HA-CA to silica at pH 5.5 and structural hardness with cohesive coupling at pH 7.4. In addition, after core removal, the hollow HA-CA particles are followed by loading of anticancer drug, doxorubicin (DOX). DOX loaded HA-CA particles show pH-triggered release behavior and dramatic cytotoxic effect indicating that they are a promising novel anticancer drug carrier. (C) 2017 Elsevier Ltd. All rights reserved.
- URI
- https://www.sciencedirect.com/science/article/pii/S0144861717301297?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/114035
- ISSN
- 0144-8617; 1879-1344
- DOI
- 10.1016/j.carbpol.2017.02.009
- Appears in Collections:
- COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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