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Hollow hyaluronic acid particles by competition between adhesive and cohesive properties of catechol for anticancer drug carrier

Title
Hollow hyaluronic acid particles by competition between adhesive and cohesive properties of catechol for anticancer drug carrier
Author
이수재
Keywords
Hyaluronic acid; Catechol; Redox transition; Adhesive; pH triggered release
Issue Date
2017-05
Publisher
ELSEVIER SCI LTD
Citation
CARBOHYDRATE POLYMERS, v. 164, page. 309-316
Abstract
The marine mussel-inspired properties of catechol, adhesiveness and cohesiveness, have been applied with pH control to fabricate hollow particles using a silica core and catechol-modified hyaluronic acid (HA-CA) shell for an anticancer drug carrier. The competition between adhesive and cohesive properties of catechol with different pH values leads to various structures, a rough catechol modified HA (HA-CA) shell at pH 5.5, monodisperse spherical silica@HA-CA particles at pH 7.4, and an amorphous HA-CA layer at pH 8.5. The redox transition of catechol with pH is a key factor modulating the behavior of the HA-CA shell on the silica core, which induces strong adhesion of HA-CA to silica at pH 5.5 and structural hardness with cohesive coupling at pH 7.4. In addition, after core removal, the hollow HA-CA particles are followed by loading of anticancer drug, doxorubicin (DOX). DOX loaded HA-CA particles show pH-triggered release behavior and dramatic cytotoxic effect indicating that they are a promising novel anticancer drug carrier. (C) 2017 Elsevier Ltd. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0144861717301297?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/114035
ISSN
0144-8617; 1879-1344
DOI
10.1016/j.carbpol.2017.02.009
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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