Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 류재숙 | - |
dc.date.accessioned | 2019-11-25T02:21:02Z | - |
dc.date.available | 2019-11-25T02:21:02Z | - |
dc.date.issued | 2017-05 | - |
dc.identifier.citation | PARASITOLOGY INTERNATIONAL, v. 66, no. 5, page. 619-621 | en_US |
dc.identifier.issn | 1383-5769 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1383576917301824?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/114004 | - |
dc.description.abstract | Metronidazole is well known for medicine against Trichomonas vaginalis infection, but it has side effects though it is effective, and especially because reports of metronidazole-tolerant species are increasing, the development of new medicine is being required. Here, we noticed the killing effects of endoperoxide compounds, N-89 and N-251 as new antimalarial drug candidates, on T. vaginalis and searched the possibility of development of new medicine. We added each of metronidazole, artemisinin, and two of new endoperoxides (N-89 and N-251) to metronidazole-resistant and -sensitive species and compared its anti-trichomonal efficacy. For metronidazole, IC50 value, 50% of killing concentration for T. vaginalis, was very low for metronidazole-sensitive isolates (11.7 to 22.8 mu M), but was high for metronidazole-resistant ones (182.9 to 730.4 mu M). The IC50 values of N-89 and N-251 were 41.0 to 60.0 mu M, and 82.0 to 300.0 mu M for metronidazole-sensitive and-resistant isolates, respectively. In conclusion, we found the endoperoxides, N-89 and N-251, have anti-trichomonal effect against metronidazole-resistant T. vaginalis as well as metronidazole-sensitive ones. These results indicate that the anti-richomonal effects for our endoperoxides are equivalent or better in metronidazole-resistant T. vaginalis in comparison to metronidazole. | en_US |
dc.description.sponsorship | This research was supported by a grant from the Korea National Institute of Health, Korea Centers for Disease Control and Prevention (2011E5400600, J.-S. Ryu). In addition, this work was partially supported by Grant-in-Aid for Scientific Research (B) (JP25305008, H.-S. Kim), and Grant-in-Aid for Scientific Research (C) (JP22590099, H.-S. Kim) from the Ministry of Education, Culture, Sports, Science and Technologies, Japan. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER IRELAND LTD | en_US |
dc.subject | Trichomonas vaginalis | en_US |
dc.subject | 1,2,6,7-tetraoxaspiro[7.11]nonadecane (N-89) | en_US |
dc.subject | 6-(1,2,6,7-Tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) | en_US |
dc.subject | Anti-trichomonal activity | en_US |
dc.subject | Endoperoxides | en_US |
dc.subject | Metronidazole-resistant isolate | en_US |
dc.title | Potential of synthetic endoperoxides against Trichomonas vaginalis in vitro | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 66 | - |
dc.identifier.doi | 10.1016/j.parint.2017.05.008 | - |
dc.relation.page | 619-621 | - |
dc.relation.journal | PARASITOLOGY INTERNATIONAL | - |
dc.contributor.googleauthor | Seo, Min-Young | - |
dc.contributor.googleauthor | Ryu, Jae-Sook | - |
dc.contributor.googleauthor | Sato, Akira | - |
dc.contributor.googleauthor | Kurosaki, Yuji | - |
dc.contributor.googleauthor | Chang, Kyung-Soo | - |
dc.contributor.googleauthor | Kim, Hye-Sook | - |
dc.relation.code | 2017006506 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jsryu | - |
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